News Column

Findings on Gene Therapy Described by Researchers at Shandong University (Recent advances in active hepatic targeting drug delivery system)

July 3, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Researchers detail new data in Biotechnology. According to news reporting originating from Jinan, People's Republic of China, by NewsRx correspondents, research stated, "Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases."

Our news editors obtained a quote from the research from Shandong University, "For example, Zinostatin stimalamer (trade name of Smancs()), a drug-polymer conjugate, was launched in Japan in 1994, which treats hepatocellular carcinoma. More improtantly, different measures would be taken in accord to the specified cell that was lesioned or dysfunctioned via interaction between homing ligands and target receptors so as to improve accumulation of drugs in the target cell and to reduce nonspecific toxicity towards other cells or organs. Therefore, it is urgent to design novel delivery systems that physically or chemically grafted homing devices in order to improve the targeting properties of drugs in specific cell sites."

According to the news editors, the research concluded: "From that perspective, the present article highlights recent development of active hepatic targeting drug/gene delivery systems for the treatment of hepatic diseases that were mediated by some kinds of receptors including asialoglycoprotein receptors (ASGP-R), glycyrrhetinic acid receptor (GA-R), glycyrrhizin receptor (GL-R), hyaluronan receptor (HA-R) and so on."

For more information on this research see: Recent advances in active hepatic targeting drug delivery system. Current Drug Targets, 2014;15(6):573-99. (Bentham Science Publishers -; Current Drug Targets -

The news editors report that additional information may be obtained by contacting Y. Wang, Dept. of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, People's Republic of China. Additional authors for this research include H. Du and G. Zhai (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Jinan, Gene Therapy, Bioengineering, Drug Delivery Systems, People's Republic of China.

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Source: Gene Therapy Weekly

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