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Findings from National Taiwan University Provide New Insights into Biomolecular Sensing (A CMOS wireless biomolecular sensing system-on-chip based on...

July 2, 2014



Findings from National Taiwan University Provide New Insights into Biomolecular Sensing (A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biomolecular Sensing. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "As developments of modern societies, an on-field and personalized diagnosis has become important for disease prevention and proper treatment. To address this need, in this work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed and fabricated by a 0.35 ?m 2-Poly-4-Metal (2P4M) complementary metal-oxide-semiconductor (CMOS) process provided by a commercialized semiconductor foundry."

Our news journalists obtained a quote from the research from National Taiwan University, "Because of the advantages of CMOS system-on-chip (SoC) technologies, the poly-Si NW biosensor is integrated with a chopper differential-difference amplifier (DDA) based analog-front-end (AFE), a successive approximation analog-to-digital converter (SAR ADC), and a microcontroller to have better sensing capabilities than a traditional Si NW discrete measuring system. In addition, an on-off key (OOK) wireless transceiver is also integrated to form a wireless bio-SSoC technology. This is pioneering work to harness the momentum of CMOS integrated technology into emerging bio-diagnosis technologies. This integrated technology is experimentally examined to have a label-free and low-concentration biomolecular detection for both Hepatitis B Virus DNA (10 fM) and cardiac troponin I protein (3.2 pM). Based on this work, the implemented wireless bio-SSoC has demonstrated a good biomolecular sensing characteristic and a potential for low-cost and mobile applications."

According to the news editors, the research concluded: "As a consequence, this developed technology can be a promising candidate for on-field and personalized applications in biomedical diagnosis."

For more information on this research see: A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology. Lab On a Chip - Miniaturisation for Chemistry and Biology, 2013;13(22):4451-9 (see also Biomolecular Sensing).

The news correspondents report that additional information may be obtained from C.W. Huang, Graduate Institute of Electronics Engineering, National Taiwan University, Taipei 10617, Taiwan. Additional authors for this research include Y.J. Huang, P.W. Yen, H.H. Tsai, H.H. Liao, Y.Z. Juang, S.S. Lu and C.T Lin.

Keywords for this news article include: Asia, Taipei, Taiwan, Biosensing, Electronics, Semiconductor, Bioengineering, Bionanotechnology, Nanobiotechnology, Biomolecular Sensing, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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