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Findings from Karolinska University Hospital Yields New Data on Tissue Engineering (Constructs of electrospun PLGA, compressed collagen and minced...

July 2, 2014



Findings from Karolinska University Hospital Yields New Data on Tissue Engineering (Constructs of electrospun PLGA, compressed collagen and minced urothelium for minimally manipulated autologous bladder tissue expansion)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Biomedicine and Biomedical Engineering have been presented. According to news reporting out of Stockholm, Sweden, by NewsRx editors, research stated, "Bladder regeneration based on minced bladder mucosa in vivo expansion is an alternative to in vitro culturing of urothelial cells. Here, we present the design of a hybrid, electrospun poly(lactic-co-glycolide) (PLGA) - plastically compressed (PC) collagen scaffold that could allow in vivo bladder mucosa expansion."

Our news journalists obtained a quote from the research from Karolinska University Hospital, "Optimisation of electrospinning was performed in order to obtain increased pore sizes and porosity to consolidate the construct and to support neovascularisation and tissue ingrowth. Tensile tests showed an increase in average tensile strength from 0.6 MPa for PC collagen to 3.57 MPa for the hybrid construct. The optimised PLGA support scaffold was placed between two collagen gels, and the minced tissue was distributed either on top or both on top and inside the construct prior to PC; this was then cultured for up to four weeks. Morphology, histology and SEM demonstrated that the construct maintained its integrity throughout cell culture. Cells from minced tissue migrated, expanded and re-organised to a confluent cell layer on the top of the construct after two weeks and formed a multilayered urothelium after four weeks."

According to the news editors, the research concluded: "Cell morphology and phenotype was typical for urothelial mucosa during tissue culture."

For more information on this research see: Constructs of electrospun PLGA, compressed collagen and minced urothelium for minimally manipulated autologous bladder tissue expansion. Biomaterials, 2014;35(22):5741-5748. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting F. Ajalloueian, Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Dept. of Paediat Surg, Stockholm, Sweden. Additional authors for this research include S. Zeiai, M. Fossum and J.G. Hilborn (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, Sweden, Europe, Collagen, Stockholm, Bioengineering, Extracellular Matrix Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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