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Data on Molecular Therapeutics Described by Researchers at University of Iowa (Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy)

July 2, 2014



By a News Reporter-Staff News Editor at Biotech Week -- A new study on Biotechnology is now available. According to news reporting out of Iowa City, Iowa, by NewsRx editors, research stated, "While microRNAs (miRNAs) clearly regulate multiple pathways integral to disease development and progression, the lack of safe and reliable means for specific delivery of miRNAs to target tissues represents a major obstacle to their broad therapeutic application. Our objective was to explore the use of nucleic acid aptamers as carriers for cell-targeted delivery of a miRNA with tumor suppressor function, let-7g."

Our news journalists obtained a quote from the research from the University of Iowa, "Using an aptamer that binds to and antagonizes the oncogenic receptor tyrosine kinase Axl (GL21. T), here we describe the development of aptamer-miRNA conjugates as multifunctional molecules that inhibit the growth of Axl-expressing tumors. We conjugated the let-7g miRNA to GL21. T and demonstrate selective delivery to target cells, processing by the RNA interference machinery, and silencing of let-7g target genes. Importantly, the multifunctional conjugate reduced tumor growth in a xenograft model of lung adenocarcinoma."

According to the news editors, the research concluded: "Therefore, our data establish aptamer-miRNA conjugates as a novel tool for targeted delivery of miRNAs with therapeutic potential."

For more information on this research see: Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy. Molecular Therapy, 2014;22(6):1151-1163. Molecular Therapy can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Elsevier - www.elsevier.com; Molecular Therapy - www.elsevier.com/wps/product/cws_home/622922)

Our news journalists report that additional information may be obtained by contacting C.L. Esposito, University of Iowa, Mol & Cellular Biol Program, Iowa City, IA, United States. Additional authors for this research include L. Cerchia, S. Catuogno, G. De Vita, J.P. Dassie, G. Santamaria, P. Swiderski, G. Condorelli, P.H. Giangrande and V. de Franciscis (see also Biotechnology).

Keywords for this news article include: Biotechnology, Cancer, Therapy, Genetics, Oncology, Iowa City, United States, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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