Data on Liposomes Reported by Researchers at Sichuan University (Increased tumor targeted delivery using a multistage liposome system functionalized with RGD, TAT and cleavable PEG)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news reporting originating in Chengdu, People's Republic of China, by NewsRx journalists, research stated, "Though PEGylation has been widely used to enhance the accumulation of liposomes in tumor tissues through enhanced permeability and retention (EPR) effects, it still inhibits cellular uptake and affects intracellular trafficking of carriers. Active targeting molecules displayed better cell selectivity but were shadowed by the poor tumor penetration effect."
The news reporters obtained a quote from the research from Sichuan University, "Cell penetrating peptides could increase the uptake of the carriers but were limited by their non-specificity. Dual-ligand system may possess a synergistic effect and create a more ideal drug delivery effect. Based on the above factors, we designed a multistage liposome system co-modified with RGD, TAT and cleavable PEG, which combined the advantages of PEG, specific ligand and penetrating peptide. The cleavable PEG could increase the stability and circulation time of liposomes during circulation. After the passive extravasation to tumor tissues, the previously hidden dual ligands on the liposomes were exposed in a controlled manner at the tumor site through exogenous administration of a safe reducing agent L-cysteine. The RGD specifically recognized the integrins overexpressed on various malignant tumors and mediated efficient internalization in the synergistic effect of the RGD and TAT. In vitro cellular uptake and 3D tumor spheroids penetration studies demonstrated that the system could not only be selectively and efficiently taken up by cells overexpress ingintegrins but also penetrate the tumor cells to reach the depths of the avascular tumor spheroids. In vivo imaging and fluorescent images of tumor section further demonstrated that this system achieved profoundly improved distribution within tumor tissues, and the RGD and TAT ligands on C-R/T liposomes produced a strong synergistic effect that promoted the uptake of liposomes into cells after the systemic administration of L-cysteine."
According to the news reporters, the research concluded: "The results of this study demonstrated a tremendous potential of this multistage liposomes for efficient delivery to tumor tissue and selective internalization into tumor cells."
For more information on this research see: Increased tumor targeted delivery using a multistage liposome system functionalized with RGD, TAT and cleavable PEG. International Journal of Pharmaceutics, 2014;468(1-2):26-38. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news correspondents report that additional information may be obtained by contacting L. Mei, Sichuan University, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, People's Republic of China. Additional authors for this research include L. Fu, K.R. Shi, Q.Y. Zhang, Y.Y. Liu, J. Tang, H.L. Gao, Z.R. Zhang and Q. He (see also Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Chengdu, Therapy, Liposomes, Drug Delivery Systems, People's Republic of China
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