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Cornell University Reports Findings in Drug Delivery Systems (In vitro models of tumor vessels and matrix: Engineering approaches to investigate...

July 2, 2014



Cornell University Reports Findings in Drug Delivery Systems (In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting out of Ithaca, New York, by NewsRx editors, research stated, "Tumor-stroma interactions have emerged as critical determinants of drug efficacy. However, the underlying biological and physicochemical mechanisms by which the microenvironment regulates therapeutic response remain unclear, due in part to a lack of physiologically relevant in vitro platforms to accurately interrogate tissue-level phenomena."

Our news journalists obtained a quote from the research from Cornell University, "Tissue-engineered tumor models are beginning to address this shortcoming. By allowing selective incorporation of microenvironmental complexity, these platforms afford unique access to tumor-associated signaling and transport dynamics. This review will focus on engineering approaches to study drug delivery as a function of tumor-associated changes of the vasculature and extracellular matrix (ECM). First, we review current biological understanding of these components and discuss their impact on transport processes."

According to the news editors, the research concluded: "Then, we evaluate existing microfluidic, tissue engineering, and materials science strategies to recapitulate vascular and ECM characteristics of tumors, and finish by outlining challenges and future directions of the field that may ultimately improve anti-cancer therapies."

For more information on this research see: In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer. Advanced Drug Delivery Reviews, 2014;69():205-216. Advanced Drug Delivery Reviews can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Advanced Drug Delivery Reviews - www.elsevier.com/wps/product/cws_home/505508)

Our news journalists report that additional information may be obtained by contacting B.R. Seo, Cornell University, Kavli Inst Cornell Nanoscale Sci, Ithaca, NY 14853, United States. Additional authors for this research include P. DelNero and C. Fischbach (see also Drugs and Therapies).

Keywords for this news article include: Tissue Engineering, Ithaca, Cancer, New York, Oncology, United States, Drugs and Therapies, Drug Delivery Systems, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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