News Column

Researchers from Shenyang Pharmaceutical University Report Details of New Studies and Findings in the Area of Natural Product Research

June 24, 2014

By a News Reporter-Staff News Editor at Journal of Technology -- Researchers detail new data in Natural Product Research. According to news reporting originating from Shenyang, People's Republic of China, by VerticalNews correspondents, research stated, "Curdione (1), a sesquiterpene with a germacrane skeleton from rhizomes of Curcuma wenyujin, has attracted attention due to its important pharmacological properties. Herein, we investigated the chemo-biotransformation of curdione (1) systematically using Aspergillus niger AS 3.739."

Our news editors obtained a quote from the research from Shenyang Pharmaceutical University, "Regio-and stereoselective hydroxylation of curdione with filamentous fungus A. niger AS 3.739 led to seven metabolites including four new compounds 3?-hydroxycurcumalactone, 2?-hydroxycurcumalactone, (10S)-9,10-dihydroxy-curcumalactone and (10R)-9,10-dihydroxy-curcumalactone. Their structures were determined by spectroscopic techniques including two-dimensional NMR and TOF-MS (Time of Flight Mass Spectrometry). Based upon the analysis of biological and chemical conversions of curdione, a tentative metabolic pathway via chemo-bio cascade reactions is proposed in A. niger system, which provides an insight into the corresponding metabolism of curdione in animal systems."

According to the news editors, the research concluded: "In addition, experiments with selected monooxygenase inhibitors suggest that cytochrome P450 monooxygenase played a crucial role in the hydroxylation of curdione."

For more information on this research see: An insight into the curdione biotransformation pathway by Aspergillus niger. Natural Product Research, 2014;28(7):454-60.

The news editors report that additional information may be obtained by contacting Y. Chen, a School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang 110016 , People's Republic of China. Additional authors for this research include L. Zhang, B. Qin, X. Zhang, X. Jia, X. Wang, D. Jin and S. You.

Keywords for this news article include: Asia, Shenyang, Natural Product Research, People's Republic of China.

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Source: Journal of Technology