News Column

Patent Issued for Chemical Sensor with Conductive Cup-Shaped Sensor Surface

June 24, 2014



By a News Reporter-Staff News Editor at Journal of Technology -- Life Technologies Corporation (Carlsbad, CA) has been issued patent number 8747748, according to news reporting originating out of Alexandria, Virginia, by VerticalNews editors.

The patent's inventors are Li, Shifeng (Fremont, CA); Bustillo, James (Castro Valley, CA); Hinz, Wolfgang (Killingworth, CT).

This patent was filed on January 19, 2012 and was published online on June 10, 2014.

From the background information supplied by the inventors, news correspondents obtained the following quote: "Electronic sensor arrays are finding increased use for detecting analytes in fluids, such as gases or liquids. In particular, arrays of sensors based on field effect transistors are finding use in detecting ionic components, such as various cations, anions or pH. Such sensors are often referred to as ion-sensitive field effect transistors or ISFETs.

"Recently, such sensor arrays have found use in sequencing polynucleotides. Nucleotide addition results in the release of ionic species that influence the pH in a local environment. Sensors of the sensor arrays are used to detect changes in pH in the local environment resulting from the nucleotide addition. However, the pH of the local environment can be influenced by the interaction of various materials with hydrogen ions, leading to lower accuracy and less sensitivity to changes caused by nucleotide addition.

"As such, an improved sensor array would be desirable."

Supplementing the background information on this patent, VerticalNews reporters also obtained the inventors' summary information for this patent: "In a first aspect, a system includes a sensor including a sensor pad and a well wall structure defining a well operatively coupled to the sensor pad. The well is further defined by a lower surface disposed over the sensor pad. The well wall structure defines an upper surface and defines a wall surface extending between the upper surface and the lower surface. A conductive layer is disposed over the lower surface and at least a portion of the wall surface.

"In a second aspect, a system includes an array of sensors, each sensor of the array of sensors including a sensor pad and a well wall structure defining a plurality of wells. Each well is operatively coupled to an associated sensor pad. Each well is further defined by a lower surface disposed over the associated sensor pad. The well wall structure defines an upper surface and defines, for each well, a wall surface extending between the upper surface and the lower surface. In association with a well of the plurality of wells, a conductive layer is disposed over the lower surface and at least a portion of the wall surface.

"In a third aspect, a method of forming a sensor system includes forming a well wall structure defining a well operatively coupled to a sensor pad of a sensor. The well is further defined by a lower surface disposed over the sensor pad. The well wall structure defines an upper surface and defines a wall surface extending between the upper surface and the lower surface. The method further includes depositing a conductive layer over the well wall structure. The conductive layer overlies the upper surface, wall surface and lower surface. The method also includes planarizing to remove the conductive layer from the upper surface.

"In a fourth aspect, a method of sequencing a polynucleotide includes depositing a polynucleotide conjugated polymeric particle in a well of a system. The system includes a sensor including a sensor pad and a well wall structure defining a well operatively coupled to the sensor pad. The well is further defined by a lower surface disposed over the sensor pad. The well wall structure defines an upper surface and defines a wall surface extending between the upper surface and the lower surface. The system further includes a conductive layer disposed over the lower surface and at least a portion of the wall surface. The method further includes applying a solution including a nucleotide to the well and observing the sensor to detect nucleotide incorporation."

For the URL and additional information on this patent, see: Li, Shifeng; Bustillo, James; Hinz, Wolfgang. Chemical Sensor with Conductive Cup-Shaped Sensor Surface. U.S. Patent Number 8747748, filed January 19, 2012, and published online on June 10, 2014. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8747748.PN.&OS=PN/8747748RS=PN/8747748

Keywords for this news article include: Life Technologies Corporation.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Journal of Technology