News Column

New Nanorings Findings Has Been Reported by Investigators at University of Minnesota

June 25, 2014

By a News Reporter-Staff News Editor at Journal of Engineering -- Data detailed on Nanorings have been presented. According to news reporting from Minneapolis, Minnesota, by VerticalNews journalists, research stated, "The ability to engineer and re-program the surfaces of cells would provide an enabling synthetic biological method for the design of cell- and tissue-based therapies. A new cell surface-engineering strategy is described that uses lipid-chemically self-assembled nanorings (lipid-CSANs) that can be used for the stable and reversible modification of any cell surface with a molecular reporter or targeting ligand."

The news correspondents obtained a quote from the research from the University of Minnesota, "In the presence of a non-toxic FDA-approved drug, the nanorings were quickly disassembled and the cell-cell interactions reversed. Similar to T-cells genetically engineered to express chimeric antigen receptors (CARS), when activated peripheral blood mononuclear cells (PBMCs) were functionalized with the anti-EpCAM-lipid-CSANs, they were shown to selectively kill antigen-positive cancer cells."

According to the news reporters, the research concluded: "Taken together, these results demonstrate that lipid-CSANs have the potential to be a rapid, stable, and general method for the reversible engineering of cell surfaces and cell-cell interactions."

For more information on this research see: Reversible Re-programing of Cell-Cell Interactions. Angewandte Chemie-International Edition, 2014;53(20):5112-5116. Angewandte Chemie-International Edition can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany.

Our news journalists report that additional information may be obtained by contacting K. Gabrielse, University of Minnesota, Dept. of Chem, Minneapolis, MN 55455, United States. Additional authors for this research include A. Gangar, N. Kumar, J.C. Lee, A. Fegan, J.J. Shen, Q. Li, D. Vallera and C.R. Wagner.

Keywords for this news article include: Minnesota, Minneapolis, Engineering, United States, Nanotechnology, Emerging Technologies, North and Central America

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Source: Journal of Engineering

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