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New Intercellular Signaling Peptides and Proteins Study Results from Nanjing University Described

June 27, 2014

By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Intercellular Signaling Peptides and Proteins are presented in a new report. According to news reporting out of Jiangsu, People's Republic of China, by NewsRx editors, research stated, "Aptamer-silver decahedral nanoparticles (Ag10NPs-aptamer) based detection was developed for protein. Ag(10)NPs were synthesized by photochemical method."

Our news journalists obtained a quote from the research from Nanjing University, "The advantage of Ag(10)NPs was its tolerance of NaCl which facilitates the functionalization of silver nanoparticles with all kinds of ssDNA. Attaching aptamers to Ag(10)NPs could be achieved within 2 h, much faster than traditional methods. Human platelet-derived growth factor-BB (PDGF-BB) was used as a model protein to test the binding capacity of aptamers attached on Ag(10)NPs. Our data showed that the aptamer-Ag(10)NPs conjugates were successful in detecting human PDGF-BB. Furthermore, we developed an aptamer-Ag(10)NPs conjugates-based colorimetric sensor to detect PDGF-BB. The results showed a linear relationship between PDGF-BB concentrations (5 ng mL (1)-200 ng mL (1)) and Delta OD with excellent detection specificity in serum."

According to the news editors, the research concluded: "Therefore, the sensor based on aptamer-Ag(10)NPs conjugates was highly effective and sensitive and had great promise for further development and applications."

For more information on this research see: Fast functionalization of silver decahedral nanoparticles with aptamers for colorimetric detection of human platelet-derived growth factor-BB. Analytica Chimica Acta, 2014;829():48-53. Analytica Chimica Acta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Analytica Chimica Acta -

Our news journalists report that additional information may be obtained by contacting H. Li, Nanjing University, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing, Jiangsu, People's Republic of China. Additional authors for this research include Y. Zhu, S.Y. Dong, W.B. Qiang, L. Sun and D.K. Xu (see also Intercellular Signaling Peptides and Proteins).

Keywords for this news article include: Asia, Jiangsu, Nanoparticle, Blood Proteins, Nanotechnology, Emerging Technologies, People's Republic of China, Platelet-Derived Growth Factor, Intercellular Signaling Peptides and Proteins

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Source: Science Letter

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