News Column

Investigators from Department of Biotechnology Have Reported New Data on Nanoparticles

June 27, 2014

By a News Reporter-Staff News Editor at Science Letter -- Current study results on Nanoparticles have been published. According to news originating from Tamil Nadu, India, by NewsRx correspondents, research stated, "An efficient and eco-friendly protocol for the synthesis of bioactive silver nanoparticles was developed using Naringi crenulata leaf extracts via microwave irradiation method. Silver nanoparticles were synthesized by treating N. crenulata leaf extracts with 1 mM of aqueous silver nitrate solution."

Our news journalists obtained a quote from the research from the Department of Biotechnology, "An effective bioactive compound such as alkaloids, phenols, saponins and quinines present in the N. crenulata reduces the Ag+ into Ag-0. The synthesized silver nanoparticles were monitored by UV-vis spectrophotometer and further characterized by X-ray diffraction (XRD), Fourier Transform Infra Red (FTIR), Energy-dispersive Xray spectroscopy (EDX) and field emission scanning electron microscopy (FESEM). UV-vis spectroscopy showed maximum absorbance at 390 nm due to surface plasmon resonance of AgNPs. From FESEM results, an average crystal size of the synthesized nanoparticle was 72-98 nm. FT-IR results showed sharp absorption peaks and they were assigned to phosphine, alkyl halides and sulfonate groups. Silver nanoparticles synthesized were generally found to be spherical and cubic shape. Topical application of ointment prepared from silver nanoparticles of N. crenulata were formulated and evaluated in vivo using the excision wound healing model on Wistar albino rats. The measurement of the wound areas was performed on 3rd, 6th, 9th, 12th and 15th days and the percentage of wound closures was calculated accordingly. By the 15th day, the ointment base containing 5% (w/w) of silver nanoparticles showed 100% wound healing activity compared with that of the reference as well as control bases."

According to the news editors, the research concluded: "The results strongly suggested that the batch C ointment containing silver nanaoparticles synthesized from the leaf extracts of N. crenulata was found to be very effective in wound repair and encourages harnessing the potentials of the plant biomolecules loaded silver nanoparticle in the treatment of tropical diseases including wound healing."

For more information on this research see: Bioactive compound loaded stable silver nanoparticle synthesis from microwave irradiated aqueous extracellular leaf extracts of Naringi crenulata and its wound healing activity in experimental rat model. Acta Tropica, 2014;135():55-61. Acta Tropica can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Acta Tropica -

The news correspondents report that additional information may be obtained from T. Bhuvaneswari, Mother Teresa Womens Univ, Dept. of Biotechnol, Kodaikanal 624101, Tamil Nadu, India. Additional authors for this research include M. Thiyagarajan, N. Geetha and P. Venkatachalam (see also Nanoparticles).

Keywords for this news article include: Asia, India, Tamil Nadu, Nanotechnology, Emerging Technologies

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Source: Science Letter

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