News Column

Investigators at Capital Normal University Report Findings in Fetal Proteins

June 27, 2014

By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Proteins. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "In this work, poly(diallyldimethylammonium chloride) (PDDA) protected Prussian blue/gold nano-particles/ ionic liquid functionalized reduced graphene oxide (IL-rGO-Au-PDDA-PB) nanocomposite was fabricated. The resulting nanocomposite exhibited high biocompatibility, conductivity and catalytic activity."

Our news journalists obtained a quote from the research from Capital Normal University, "To assess the performance of the nanocomposite, a sensitive sandwich-type immunosensor was constructed for detecting alpha-fetoprotein (AFP). Greatly enhanced sensitivity for this immunosensor was based on triple signal amplification strategies. Firstly, IL-rGO modified electrode was used as biosensor platform to capture a large amount of antibody due to its increased surface area, thus amplifying the detection response. Secondly, a large number of Au-PDDA-PB was conjugated on the surface of IL-rGO, which meant the enrichment of the signal and the more immobilization of label antibody. Finally, the catalytic reaction between H2O2 and the IL-rGO-Au-PDDA-PB nanocomposite further enhanced the signal response. The signals increased linearly with AFP concentrations in the range of 0.01-100 ng mL (1). The detection limit for AFP was 4.6 pg mL (1). The immunosensor showed high sensitivity, excellent selectivity and good stability."

According to the news editors, the research concluded: "Moreover, the immunosensor was applied to the analysis of AFP in serum sample with satisfactory result."

For more information on this research see: Prussian blue-gold nanoparticles-ionic liquid functionalized reduced graphene oxide nanocomposite as label for ultrasensitive electrochemical immunoassay of alpha-fetoprotein. Analytica Chimica Acta, 2014;829():15-21. Analytica Chimica Acta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Analytica Chimica Acta -

Our news journalists report that additional information may be obtained by contacting Q. Gao, Capital Normal Univ, Dept. of Chem, Beijing 100048, People's Republic of China. Additional authors for this research include N. Liu and Z.F. Ma (see also Proteins).

Keywords for this news article include: Asia, Beijing, Solvents, Chemistry, Ionic Liquids, Prussian Blue, Fetal Proteins, Nanotechnology, Electrochemical, Gold Nanoparticles, alpha-Fetoproteins, Emerging Technologies, Biological Tumor Markers, People's Republic of China

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Source: Science Letter

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