News Column

Data from Drexel University Provide New Insights into Hydrocephalus

June 23, 2014



By a News Reporter-Staff News Editor at Nanotechnology Business Journal -- A new study on Nervous System Diseases and Conditions is now available. According to news reporting originating from Philadelphia, Pennsylvania, by VerticalNews correspondents, research stated, "We present a microfabricated 10 by 10 array of microneedles for the treatment of a neurological disease called communicating hydrocephalus. Together with the previously reported microvalve array, the current implantable microneedle array completes the microfabricated arachnoid granulations (MAGs) that mimic the function of normal arachnoid granulations."

Our news editors obtained a quote from the research from Drexel University, "The microneedle array was designed to enable the fixation of the MAGs through dura mater membrane in the brain and thus provide a conduit for the flow of cerebrospinal fluid. Cone-shaped microneedles with hollow channels were fabricated using a series of microfabrication techniques: SU-8 photolithography for tapered geometry, reactive ion etching for sharpening the microneedles, 248 nm deep UV excimer laser machining for creating through-hole inside the microneedles, and metal sputtering for improved rigidity. Puncture tests were conducted using porcine dura mater and the results showed that the fabricated microneedle array is strong enough to pierce the dura mater. The in vitro biocompatibility test result showed that none of the 100 outlets of the microneedles exposed to the bloodstream were clogged significantly by blood cells."

According to the news editors, the research concluded: "We believe that these test results demonstrate the potential use of the microneedle array as a new treatment of hydrocephalus."

For more information on this research see: A novel microneedle array for the treatment of hydrocephalus. Microsystem Technologies-Micro-And Nanosystems-Information Storage and Processing Systems, 2014;20(6):1169-1179. Microsystem Technologies-Micro-And Nanosystems-Information Storage and Processing Systems can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA.

The news editors report that additional information may be obtained by contacting J. Oh, Drexel University, Coll Med, Philadelphia, PA 19104, United States. Additional authors for this research include K.W. Liu, T. Medina, F. Kralick and H. Noh.

Keywords for this news article include: Philadelphia, Pennsylvania, United States, Hydrocephalus, North and Central America, Central Nervous System Diseases, Nervous System Diseases and Conditions

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Source: Nanotechnology Business Journal