By a News Reporter-Staff News Editor at Clinical Oncology Week -- Investigators publish new report on Enzymes and Coenzymes. According to news reporting originating from Jinan, People's Republic of China, by NewsRx correspondents, research stated, "Determination of squamous cell carcinoma antigen (SCCA) in human serum plays an important role in diagnosis of cervical squamous cell carcinoma. In this work, Au/Ag/Au core/double shell nanoparticles (Au/Ag/Au NPs) were prepared by a simple approach and were used as novel enzyme-mimetic labels for development of a sandwich-type electrochemical immunosensor for SCCA."
Our news editors obtained a quote from the research from the University of Jinan, "The nanostructure of Au/Ag/Au NPs could be well confirmed by transmission electron microscope (TEM) and UV-vis spectra. Au NPs decorated mercapto-functionalized graphene sheets (Au@SH-GS) were used as platform for immobilization of primary antibody (Ab(1)), while Au/Ag/Au NPs were employed as labels of secondary antibody (Ab(2)). Due to the excellent electrocatalytic activity of Au/Ag/Au NPs towards the reduction of hydrogen peroxide (H2O2), electrochemical amperometric responses to SCCA were achieved after the immuno-reaction. Under optimum conditions, the electrochemical immunosensor exhibited a wide linear range from 0.5 pg/mL to 40 ng/mL with a low detection limit of 0.18 pg/mL for SCCA."
According to the news editors, the research concluded: "The designed immunosensor displayed an excellent analytical performance with good reproducibility, high selectivity and stability."
For more information on this research see: Ultrasensitive non-mediator electrochemical immunosensors using Au/Ag/Au core/double shell nanoparticles as enzyme-mimetic labels. Talanta, 2014;124():60-66. Talanta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Talanta - www.elsevier.com/wps/product/cws_home/525438)
The news editors report that additional information may be obtained by contacting Y.L. Wang, Univ Jinan, Sch Chem & Chem Engn, Key Lab Chem Sensing & Anal Univ Shandong, Jinan 250022, People's Republic of China. Additional authors for this research include Y. Zhang, Y. Su, F. Li, H.M. Ma, H. Li, B. Du and Q. Wei (see also Enzymes and Coenzymes).
Keywords for this news article include: Asia, Jinan, Chemistry, Nanoparticle, Nanotechnology, Electrochemical, Emerging Technologies, Enzymes and Coenzymes, People's Republic of China
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