News Column

Study Results from T. Lammel et al Provide New Insights into Cytoplasmic Structures

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Cytoplasmic Structures are presented in a new report. According to news reporting originating in Madrid, Spain, by NewsRx journalists, research stated, "Graphene and graphene derivatives constitute a novel class of carbon-based nanomaterials being increasingly produced and used in technical and consumer applications. Release of graphene nanoplatelets during the life cycle of these applications may result in human and environmental exposure calling for assessment of their potential to cause harm to humans and wildlife."

The news reporters obtained a quote from the research, "This study aimed to assess the toxicity of graphene oxide (GO) and carboxyl graphene (CXYG) nanoplatelets to non-mammalian species using the fish cell line PLHC-1 as in vitro model. The cytotoxicity of GO and CXYG was assessed using different assays measuring alterations in plasma membrane integrity, metabolic activity, and lysosomal and mitochondrial function. The induction of oxidative stress was assessed by measuring intracellular reactive oxygen species (ROS) levels. Interaction with the plasma membrane and internalization of nanoplatelets were investigated by electron microscopy. Graphene nanoplatelets spontaneously penetrated through the plasma membrane and accumulated in the cytosol, where they further interacted with mitochondrial and nuclear membranes. PLHC-1 cells demonstrated significantly reduced mitochondrial membrane potential (MMP) and increased ROS levels at 16 mu g/m1 GO and CXYG (72 h), but barely any decrease in cell viability."

According to the news reporters, the research concluded: "The observation of intracellular graphene accumulations not enclosed by membranes suggests that GO and CXYG internalization in fish hepatoma cells occurs through an endocytosis-independent mechanism."

For more information on this research see: Graphene nanoplatelets spontaneously translocate into the cytosol and physically interact with cellular organelles in the fish cell line PLHC-1. Aquatic Toxicology, 2014;150():55-65. Aquatic Toxicology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Aquatic Toxicology -

Our news correspondents report that additional information may be obtained by contacting T. Lammel, Inst Nacl Invest & Tecnol Agraria & Alimentar, Dept. of Medio Ambiente, Madrid 28040, Spain (see also Cytoplasmic Structures).

Keywords for this news article include: Spain, Madrid, Europe, Organelles, Nanoplatelet, Nanotechnology, Cellular Structures, Intracellular Space, Emerging Technologies, Cytoplasmic Structures

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Source: Life Science Weekly

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