News Column

Study Results from Kyung Hee University Provide New Insights into Nanoparticles

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting out of Seoul, South Korea, by NewsRx editors, research stated, "A titanium (Ti)-adhesive nanoparticle is developed as a surface-releasing system for dual osteogenic growth factors. The Ti-adhesive nanoparticle is prepared by self-assembly of a poly(L-lactide-co-glycolide) (PLGA)-grafted hyaluronic acid (HA) copolymer, followed by conjugation of catechol groups on nanoparticle surfaces."

Our news journalists obtained a quote from the research from Kyung Hee University, "The nanoparticles consist of Ti-adhesive peripheral catechol groups, anionic HA shells, and hydrophobic PLGA inner cores. The immobilization of the nanoparticles onto Ti substrates is successfully verified using various analytical tools including field-emission scanning electron microscopy (Fe-SEM), contact angle measurement, and X-ray photoelectron spectroscopy (XPS). Positively charged dual growth factors, bone morphogenetic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) are readily loaded onto the negatively charged HA shells of surface-immobilized nanoparticles, which is confirmed by fluorescence microscopy."

According to the news editors, the research concluded: "The Ti substrates with dual growth factor-loaded nanoparticle-immobilized nanoparticles remarkably promote the attachment, proliferation, spreading, and alkaline phosphatase (ALP) activity of human adipose-derived stem cells (hADSCs)."

For more information on this research see: Titanium-Adhesive Polymer Nanoparticles as a Surface-Releasing System of Dual Osteogenic Growth Factors. Macromolecular Bioscience, 2014;14(4):496-507. Macromolecular Bioscience can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell -; Macromolecular Bioscience -

Our news journalists report that additional information may be obtained by contacting G.H. Choi, Kyung Hee Univ, Inst Oral Biol, Sch Dental, Dept. of Maxillofacial Biomed Engn, Seoul 130701, South Korea. Additional authors for this research include H.J. Lee and S.C. Lee (see also Nanoparticles).

Keywords for this news article include: Asia, Seoul, Titanium, South Korea, Light Metals, Nanotechnology, Emerging Technologies

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Source: Life Science Weekly

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