News Column

Studies from Fudan University Describe New Findings in Peptides and Proteins

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Peptides have been presented. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "Feasible design is essential to achieve ideal chemical and biological properties of nanomaterials. For the first time, new nanocomposites with a polydopamine coating on hierarchically ordered macro-/mesoporous silica functionalized with titanium ions (denoted as HOMMS-PD-Ti4+) were prepared through a facile reaction route at room temperature."

Our news journalists obtained a quote from the research from Fudan University, "The applicability of as-synthesized HOMMS-PD-Ti4+ for the selective enrichment of phosphopeptides was tested. The experimental results demonstrate that, by taking advantage of the pure phosphate-Ti4+ interface and high loading amount of Ti4+, HOMMS-PD-Ti4+ presents remarkable selectivity for phosphopeptides, even at a low molar ratio of phosphopeptides/non-phosphopeptides (1:1000) with a very rapid enrichment speed (within 1min). The superior sensitivity for low-abundant phosphopeptides and the high selectivity and effectiveness for the enrichment of phosphopeptides from human serum are also proven."

According to the news editors, the research concluded: "These outstanding features demonstrate that HOMMS-PD-Ti4+ exhibits great potential in phosphoproteome research in the future."

For more information on this research see: Titanium(IV)-Immobilized Hydrophilic Hierarchically Ordered Macro-/Mesoporous Silica for Fast Enrichment of Phosphopeptides. Chempluschem, 2014;79(5):662-666. Chempluschem can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell -; Chempluschem -

Our news journalists report that additional information may be obtained by contacting Y.H. Yan, Fudan University, Sch Pharm, Dept. of Pharmaceut Anal, Shanghai 201203, People's Republic of China. Additional authors for this research include Z.F. Zheng, Y. Li, C.H. Deng and X.M. Zhang (see also Peptides).

Keywords for this news article include: Asia, Shanghai, Titanium, Light Metals, Phosphopeptides, People's Republic of China

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Source: Life Science Weekly

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