News Column

Studies from Aix-Marseille University Provide New Data on Biophysics

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Biophysics is now available. According to news reporting originating in Marseille, France, by NewsRx journalists, research stated, "To investigate the early stages of cell-cell interactions occurring between living biological samples, imaging methods with appropriate spatiotemporal resolution are required. Among the techniques currently available, those based on optical trapping are promising."

The news reporters obtained a quote from the research from Aix-Marseille University, "Methods to image trapped objects, however, in general suffer from a lack of three-dimensional resolution, due to technical constraints. Here, we have developed an original setup comprising two independent modules: holographic optical tweezers, which offer a versatile and precise way to move multiple objects simultaneously but independently, and a confocal microscope that provides fast three-dimensional image acquisition. The optical decoupling of these two modules through the same objective gives users the possibility to easily investigate very early steps in biological interactions. We illustrate the potential of this setup with an analysis of infection by the fungus Drechmeria coniospora of different developmental stages of Caenorhabditis elegans. This has allowed us to identify specific areas on the nematode's surface where fungal spores adhere preferentially."

According to the news reporters, the research concluded: "We also quantified this adhesion process for different mutant nematode strains, and thereby derive insights into the host factors that mediate fungal spore adhesion."

For more information on this research see: Independent Synchronized Control and Visualization of Interactions between Living Cells and Organisms. Biophysical Journal, 2014;106(10):2096-2104. Biophysical Journal can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier -; Biophysical Journal -

Our news correspondents report that additional information may be obtained by contacting V. Rouger, Aix Marseille Univ, CNRS UMR 7249, Cent Marseille, Inst Fresnel, Marseille, France. Additional authors for this research include G. Bordet, C. Couillault, S. Monneret, S. Mailfert, J.J. Ewbank, N. Pujol and D. Marguet (see also Biophysics).

Keywords for this news article include: France, Europe, Marseille, Biophysics

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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