News Column

Studies Conducted at CREST Research Project on Nanoparticles Recently Reported

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting from Saitama, Japan, by NewsRx journalists, research stated, "Amphiphilic graft copolymers, poly(-glutamic acid)-graft-poly(lactide) (-PGA-g-PLA) bearing pendent poly(L-lactide) (PLLA) or poly(D-lactide) (PDLA) of different main chain lengths and grafting degrees, self-assemble in aqueous solution to form monodispersed stereocomplex nanoparticles (NPs). The mean diameter and degree of crystallinity of these stereocomplex NPs can be controlled by changing the grafting degree of the copolymers or the preparation methods."

The news correspondents obtained a quote from the research from CREST Research Project, "Moreover, the stereocomplex NPs exhibit a lower critical aggregation concentration as well as stronger thermodynamic stability compared with the corresponding isomer NPs. The surface-functionalized ability and protein encapsulation capacity of the stereocomplex NPs as potential targeting protein carriers are evaluated."

According to the news reporters, the research concluded: "Furthermore, these stereocomplex NPs have strong kinetic stability and can be expected to serve as stable delivery vehicles for pharmaceutical and biomedical applications."

For more information on this research see: Self-Assembling Stereocomplex Nanoparticles by Enantiomeric Poly(g-glutamic acid)poly(lactide) Graft Copolymers as a Protein Delivery Carrier. Macromolecular Bioscience, 2014;14(4):576-587. Macromolecular Bioscience can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell -; Macromolecular Bioscience -

Our news journalists report that additional information may be obtained by contacting Y. Zhu, Japan Sci & Technol Agcy JST, CREST, Saitama, Japan. Additional authors for this research include T. Akagi and M. Akashi (see also Nanoparticles).

Keywords for this news article include: Asia, Japan, Saitama, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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