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Shandong Agricultural University Describes Findings in Immunoglobulins

June 27, 2014



By a News Reporter-Staff News Editor at Energy Weekly News -- Investigators discuss new findings in Immunology. According to news reporting originating from Shandong, People's Republic of China, by VerticalNews correspondents, research stated, "In this work, we fabricated a novel photoelectrochemical immunosensor for assay of DNA methylation, where Bi2S3 nanorods were used as photoelectric conversion material, MBD1 protein (a kind of methyl bonding domain protein) was used as DNA methylation recognizing unit, anti-his tag antibody was used to further inhibit the photocurrent and increase the detection sensitivity. The results demonstrated that Bi2S3 possessed excellent photoelectron property."

Our news editors obtained a quote from the research from Shandong Agricultural University, "The detection conditions, such as Bi2S3 concentration, MBD1 protein concentration, incubation time of MBD1 protein, antibody concentration and antibody incubation time, were optimized. Under optimal experimental conditions, the photocurrent variation was proportional to the logarithm of methylated target DNA concentration from 10(-9) to 10(-13) M with detection limit of 3.5 x 10(-14) M (S/N=3)."

According to the news editors, the research concluded: "Moreover, the immunosensor presented high detection specificity, even distinguishing single-base mismatched sequence."

For more information on this research see: A new strategy for methylated DNA detection based on photoelectrochemical immunosensor using Bi2S3 nanorods, methyl bonding domain protein and anti-his tag antibody. Biosensors & Bioelectronics, 2014;51():103-8. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)

The news editors report that additional information may be obtained by contacting H. Yin, College of Chemistry and Material Science, Shandong Agricultural University, Taian, Shandong 271018, People's Republic of China. Additional authors for this research include B. Sun, Y. Zhou, M. Wang, Z. Xu, Z. Fu and S. Ai.

Keywords for this news article include: Asia, Antibodies, Biotechnology, Nanorod, Shandong, Immunology, DNA Research, Blood Proteins, Nanotechnology, Immunoglobulins, Photoelectrochemical, Emerging Technologies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Energy Weekly News


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