News Column

Researchers from University Erlangen-Nurnberg Report New Studies and Findings in the Area of Extracellular Matrix Proteins

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting originating in Erlangen, Germany, by NewsRx journalists, research stated, "To evaluate the antibacterial efficacy of silicate bioactive glass nanoparticles/collagen composites functionalized with tetracycline hydrochloride (TCH). Different concentrations of tetracycline hydrochloride (TCH) were incorporated on silicate bioactive glass nanoparticles/collagen composites by dipping these biomaterials for 48h at 37 degrees C in a solution of simulated body fluid (SBF) plus 0 center dot 05, 0 center dot 20 or 0 center dot 35mgml(-1) of the antibiotic."

The news reporters obtained a quote from the research from University Erlangen-Nurnberg, "TCH release was assessed in double-distilled water at 37 degrees C up to 72h. The antibacterial activity of the samples has been evaluated in two ways: inhibition zone test and plate count method. The experiments were performed in vitro up to 48h on four staphylococci strains (Staphylococcus aureus ATCC29213, ATCC25923, ATCC6538P and Staphylococcus epidermidis ATCC12228). The new composites were also tested for cytotoxicity on MG-63 human osteosarcoma cells. The results showed that the incorporation and release of TCH was dependent on the initial concentration of TCH in SBF. The biomaterials also inhibited the Staph.aureus cell growth even though the efficacy was similar for all concentration. On the other hand, no cytotoxic effects were found on osteoblast-like cells, even at the highest concentration. Considering all results, it can be concluded that the new composite acts as a suitable bioactive carrier of TCH and could have potential in the prevention of biomaterial related infections."

According to the news reporters, the research concluded: "Significance and Impact of the Study: The results suggest a potential application as wound dressing."

For more information on this research see: Evaluation of antibacterial and cytotoxic effects of nano-sized bioactive glass/collagen composites releasing tetracycline hydrochloride. Journal of Applied Microbiology, 2014;116(6):1438-1446. Journal of Applied Microbiology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Journal of Applied Microbiology -

Our news correspondents report that additional information may be obtained by contacting J. Rivadeneira, University of Erlangen Nurnberg, Inst Biomat, D-91054 Erlangen, Germany. Additional authors for this research include A.L. Di Virgilio, M.C. Audisio, A.R. Boccaccini and A.A. Gorustovich (see also Proteins).

Keywords for this news article include: Europe, Germany, Erlangen, Collagen, Hydrocarbons, Nanoparticle, Naphthacenes, Tetracyclines, Nanotechnology, Emerging Technologies, Extracellular Matrix Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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