By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Nanoparticles. According to news reporting originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Forced oscillation of spherical and rod-shaped iron oxide magnetic nanoparticles (MNPs) via low-power and low-frequency alternating magnetic field (AMF) was firstly used to kill cancer cells in vitro. After being loaded by human cervical cancer cells line (HeLa) and then exposed to a 35-kHz AMF, MNPs mechanically damaged cell membranes and cytoplasm, decreasing the cell viability."
Our news editors obtained a quote from the research from the Shanghai Institute of Applied Physics, "It was found that the concentration and morphology of the MNPs significantly influenced the cell-killing efficiency of oscillating MNPs. In this preliminary study, when HeLa cells were pre-incubated with 100 mu g/mL rod-shaped MNPs (rMNP, length of 200 +/- 50 nm and diameter of 50 to 120 nm) for 20 h, MTT assay proved that the cell viability decreased by 30.9% after being exposed to AMF for 2 h, while the cell viability decreased by 11.7% if spherical MNPs (sMNP, diameter of 200 +/- 50 nm) were used for investigation. Furthermore, the morphological effect of MNPs on cell viability was confirmed by trypan blue assay: 39.5% rMNP-loaded cells and 15.1% sMNP-loaded cells were stained after being exposed to AMF for 2 h. It was also interesting to find that killing tumor cells at either higher (500 mu g/mL) or lower (20 mu g/mL) concentration of MNPs was less efficient than that achieved at 100 mu g/mL concentration."
According to the news editors, the research concluded: "The relatively asymmetric morphological rod-shaped MNPs can kill cancer cells more effectively than spherical MNPs when being exposed to AMF by virtue of their mechanical oscillations."
For more information on this research see: Morphological effect of oscillating magnetic nanoparticles in killing tumor cells. Nanoscale Research Letters, 2014;9():1-8. Nanoscale Research Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Nanoscale Research Letters - www.springerlink.com/content/1931-7573/)
The news editors report that additional information may be obtained by contacting D.F. Cheng, Chinese Academy Sci, Shanghai Inst Appl Phys, Shanghai 201800, People's Republic of China. Additional authors for this research include X. Li, G.X. Zhang and H.C. Shi (see also Nanoparticles).
Keywords for this news article include: Asia, Cancer, Shanghai, Oncology, Nanotechnology, Emerging Technologies, Magnetic Nanoparticles, People's Republic of China
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