By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Enzymes and Coenzymes have been published. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "Hollow silica nanospheres (HSN) with low densities, large interior spaces and permeable silica shells are suitable for loading enzymes in the cavity to carry out intracellular biocatalysis. The porous shell can protect the encapsulated enzymes against proteolysis and attenuate immunological response."
Our news journalists obtained a quote from the research from National Taiwan University, "We developed a microemulsion-templating method for confining horseradish peroxidase (HRP) in the cavity of HSN. This simple one-pot enzyme encapsulation method allows entrapping of the enzyme, which retains high catalytic activity. Compared with HRP supported on solid silica spheres, HRP@HSN with thin porous silica shells displayed better enzyme activity. The small HRP@HSN (similar to 50 nm in diameter), giving satisfactory catalytic activity, can act as an intracellular catalyst for the oxidation of the prodrug indole-3-acetic acid to produce toxic free radicals for killing cancer cells."
According to the news editors, the research concluded: "We envision this kind of hollow nanosystem could encapsulate multiple enzymes or other synergistic drugs and function as therapeutic nanoreactors."
For more information on this research see: Enzyme Encapsulated Hollow Silica Nanospheres for Intracellular Biocatalysis. ACS Applied Materials & Interfaces, 2014;6(9):6883-6890. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
The news correspondents report that additional information may be obtained from F.P. Chang, National Taiwan University, Dept. of Chem, Taipei 10617, Taiwan. Additional authors for this research include Y. Hung, J.H. Chang, C.H. Lin and C.Y. Mou (see also Enzymes and Coenzymes).
Keywords for this news article include: Asia, Taipei, Taiwan, Nanosphere, Nanotechnology, Emerging Technologies, Enzymes and Coenzymes
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