Our news journalists obtained a quote from the research from
According to the news editors, the research concluded: "Suitable candidates were designed based on the predictions of the model and tested in vivo by intravital confocal fluorescence microscopy of solid tumors, which revealed that the nanoparticles aggregate in the vasculature of tumors heated to 42 degrees C and that the aggregation is reversible as the temperature reverts to 37 degrees C. Biodistribution studies showed that the most effective strategy to target the nanoparticles to tumors is to thermally cycle the tumors between 37 and 42 degrees C. These nanoparticles set the stage for the targeted delivery of a range of cancer chemotherapeutics by externally applied mild hyperthermia of solid tumors."
For more information on this research see: Rational Design of "Heat Seeking" Drug Loaded Polypeptide Nanoparticles That Thermally Target Solid Tumors.
The news correspondents report that additional information may be obtained from
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