News Column

Researchers from Duke University Report New Studies and Findings in the Area of Solid Cancer

June 23, 2014

By a News Reporter-Staff News Editor at Clinical Oncology Week -- Investigators publish new report on Oncology. According to news originating from Durham, North Carolina, by NewsRx correspondents, research stated, "This paper demonstrates the first example of targeting a solid tumor that is externally heated to 42 degrees C by 'heat seeking' drug-loaded polypeptide nanoparticles."

Our news journalists obtained a quote from the research from Duke University, "These nanoparticles consist of a thermally responsive elastin-like polypeptide (ELP) conjugated to multiple copies of a hydrophobic cancer drug. To rationally design drug-loaded nanoparticles that exhibit thermal responsiveness in the narrow temperature range between 37 and 42 degrees C, an analytical model was developed that relates ELP composition and chain length to the nanoparticle phase transition temperature."

According to the news editors, the research concluded: "Suitable candidates were designed based on the predictions of the model and tested in vivo by intravital confocal fluorescence microscopy of solid tumors, which revealed that the nanoparticles aggregate in the vasculature of tumors heated to 42 degrees C and that the aggregation is reversible as the temperature reverts to 37 degrees C. Biodistribution studies showed that the most effective strategy to target the nanoparticles to tumors is to thermally cycle the tumors between 37 and 42 degrees C. These nanoparticles set the stage for the targeted delivery of a range of cancer chemotherapeutics by externally applied mild hyperthermia of solid tumors."

For more information on this research see: Rational Design of "Heat Seeking" Drug Loaded Polypeptide Nanoparticles That Thermally Target Solid Tumors. Nano Letters, 2014;14(5):2890-2895. Nano Letters can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Nano Letters -

The news correspondents report that additional information may be obtained from J.R. McDaniel, Duke University, Dept. of Radiat Oncol, Durham, NC 27708, United States. Additional authors for this research include S.R. MacEwan, X.H. Li, D.C. Radford, C.D. Landon, M. Dewhirst and A. Chilkoti (see also Oncology).

Keywords for this news article include: Durham, Oncology, Nanoparticle, United States, Solid Cancers, North Carolina, Nanotechnology, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Clinical Oncology Week

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