News Column

Reports from University of Tokyo Provide New Insights into Nanoparticles

June 24, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Nanoparticles have been presented. According to news reporting from Tokyo, Japan, by NewsRx journalists, research stated, "Although the use of small interfering RNA (siRNA) is a promising technique for gene regulation, spatiotemporal control of the effects of siRNA must be achieved if the technique is to be safe and practical. Here, a method for spatiotemporal regulation of genes with nanoparticles containing siRNA is reported."

The news correspondents obtained a quote from the research from the University of Tokyo, "The siRNA is encapsulated in photodegradable nanoparticles that are internalized to SKOV3-Luc cells, where the siRNA is released from the nanoparticles by UV irradiation for 30s. The encapsulated siRNA only shows no gene-silencing effects, but release of the siRNA upon UV radiation leads to sequence-specific silencing of the luciferase gene in the cells."

According to the news reporters, the research concluded: "These results indicate that photodegradable siRNA-containing nanoparticles can be useful for time-and space-dependent regulation of gene expression in cells."

For more information on this research see: Gene Regulation by Intracellular Delivery and Photodegradation of Nanoparticles Containing Small Interfering RNA. Macromolecular Bioscience, 2014;14(5):626-631. Macromolecular Bioscience can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Macromolecular Bioscience - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1616-5195)

Our news journalists report that additional information may be obtained by contacting S. Murayama, University of Tokyo, Dept. of Mat Engn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan. Additional authors for this research include P. Kos, K. Miyata, K. Kataoka, E. Wagner and M. Kato (see also Nanoparticles).

Keywords for this news article include: Asia, Tokyo, Japan, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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