By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on Oncology are presented in a new report. According to news originating from Adelaide, Australia, by NewsRx correspondents, research stated, "Here, we report a study on the biocompatibility, cell uptake and in vitro delivery of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) by new nano-carriers called anodic alumina nanotubes (AANTs) for potential cancer therapy. AANTs were electrochemically engineered by a unique pulse anodization process, which enables precise control of the nanotube geometry, and used here as nanocarriers for drug delivery."
Our news journalists obtained a quote from the research from the University of Adelaide, "In vitro cytotoxicity and cell uptake of AANTs was assessed using MDA-MB231-TXSA human breast cancer cells and mouse RAW 264.7 macrophage cells. AANTs exhibited excellent biocompatibility in both cell lines over a time course of five days even at a maximum concentration of AANTs of 100 mu g mL(-1). Transmission electron microscopy and fluorescence microscopy confirmed a significant uptake of AANTs by RAW 264.7 cells and breast cancer cells. AANTs loaded with the pro-apoptotic protein Apo2L/TRAIL showed exceptional loading capacity (104 +/- 14.4 mu g mg(-1) of AANTs) and demonstrated significant decrease in viability of MDA-MB231-TXSA cancer cells due to apoptosis induction."
According to the news editors, the research concluded: "These results demonstrate that AANTs are promising nano-carriers for drug delivery applications."
For more information on this research see: Structurally engineered anodic alumina nanotubes as nano-carriers for delivery of anticancer therapeutics. Biomaterials, 2014;35(21):5517-5526. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news correspondents report that additional information may be obtained from Y. Wang, University of Adelaide, Sch Med, Discipline Surg, Adelaide, SA 5005, Australia. Additional authors for this research include A. Santos, G. Kaur, A. Evdokiou and D. Losic (see also Oncology).
Keywords for this news article include: Cancer, Adelaide, Nanotube, Oncology, Engineering, Therapeutics, Nanotechnology, Emerging Technologies, Australia and New Zealand
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