News Column

Reports from S. Sutcliffe and Colleagues Advance Knowledge in Prostate Cancer

June 24, 2014

By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Oncology have been presented. According to news reporting originating in Montreal, Canada, by NewsRx journalists, research stated, "With recent advances in high-throughput sequencing technologies, many prostate cancer risk loci have been identified, including rs10993994, a single nucleotide polymorphism (SNP) located near the MSMB gene. Variant allele (T) carriers of this SNP produce less prostate secretory protein 94 (PSP94), the protein product of MSMB, and have an increased risk of prostate cancer (approximately 25% per T allele), suggesting that PSP94 plays a protective role in prostate carcinogenesis, although the mechanisms for such protection are unclear."

The news reporters obtained a quote from the research, "We reviewed the literature on possible mechanisms for PSP94 protection for prostate cancer. One possible mechanism is tumor suppression, as PSP94 has been observed to inhibit cell or tumor growth in in vitro and in vivo models. Another novel mechanism, which we propose in this review article, is that PSP94 may protect against prostate cancer by preventing or limiting an intracellular fungal infection in the prostate. This mechanism is based on the recent discovery of PSP94's fungicidal activity in low-calcium environments (such as the cytosol of epithelial cells), and accumulating evidence suggesting a role for inflammation in prostate carcinogenesis. We provide further details of our proposed mechanism in this review article."

According to the news reporters, the research concluded: "To explore this mechanism, future studies should consider screening prostate specimens for fungi using the rapidly expanding number of molecular techniques capable of identifying infectious agents from the entire tree of life. Prostate 74:569-578, 2014."

For more information on this research see: MSMB Variation and Prostate Cancer Risk: Clues Towards a Possible Fungal Etiology. Prostate, 2014;74(6):569-578. Prostate can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Prostate -

Our news correspondents report that additional information may be obtained by contacting S. Sutcliffe, Shipshaw Labs, Montreal, PQ, Canada. Additional authors for this research include A.M. De Marzo, K.S. Sfanos and M. Laurence (see also Oncology).

Keywords for this news article include: Quebec, Canada, Montreal, Genetics, Oncology, Prostatic Neoplasms, Risk and Prevention, North and Central America, Metastatic Prostate Cancer

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Source: Cancer Weekly

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