News Column

Recent Research from University of Virginia Highlight Findings in Cardiology

June 23, 2014

By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Cardiology is the subject of a report. According to news originating from Charlottesville, Virginia, by NewsRx correspondents, research stated, "In almost all cardiac diseases, an increase in extracellular matrix (ECM) deposition or fibrosis occurs, mostly consisting of collagen I. Whereas replacement fibrosis follows cardiomyocyte loss in myocardial infarction, reactive fibrosis is triggered by myocardial stress or inflammatory mediators and often results in ventricular stiffening, functional deterioration, and development of heart failure. Given the importance of ECM deposition in cardiac disease, ECM imaging could be a valuable clinical tool."

Our news journalists obtained a quote from the research from the University of Virginia, "Molecular imaging of ECM may help understand pathology, evaluate impact of novel therapy, and may eventually find a role in predicting the extent of ECM expansion and development of personalized treatment. In the current review, we provide an overview of ECM imaging including the assessment of ECM volume and molecular targeting of key players involved in ECM deposition and degradation."

According to the news editors, the research concluded: "The targets comprise myofibroblasts, intracardiac renin-angiotensin axis, matrix metalloproteinases, and matricellular proteins."

For more information on this research see: Molecular Imaging of the Cardiac Extracellular Matrix. Circulation Research, 2014;114(5):903-915. Circulation Research can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Cardiology).

The news correspondents report that additional information may be obtained from H.J. de Haas, University of Virginia, Dept. of Radiol, Charlottesville, VA, United States. Additional authors for this research include E. Arbustini, V. Fuster, C.M. Kramer and J. Narula.

Keywords for this news article include: Virginia, Cardiology, United States, Nanotechnology, Charlottesville, Molecular Imaging, Emerging Technologies, North and Central America

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Source: Cardiovascular Week

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