News Column

Recent Findings in Medical Nanotechnology Described by Researchers from Case Western Reserve University

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Medical Nanotechnology have been published. According to news reporting originating in Cleveland, Ohio, by NewsRx journalists, research stated, "Nanoparticles based on plant viruses are emerging biomaterials for medical applications such as drug delivery and imaging. Their regular structures can undergo genetic and chemical modifications to carry large payloads of cargos, as well as targeting ligands."

The news reporters obtained a quote from the research from Case Western Reserve University, "Of several such platforms under development, only few have been characterized in vivo. We recently introduced the filamentous plant virus, potato virus X (PVX), as a new platform. PVX presents with a unique nanoarchitecture and is difficult to synthesize chemically. Here, we present a detailed analysis of PVX biodistribution and clearance in healthy mice and mouse tumor xenograft models using a combination of ex vivo whole-organ imaging, quantitative fluorescence assays and immunofluorescence microscopy. While up to 30% of the PVX signal was from the colon, mammary and brain tumor tissues, remaining particles were cleared by the reticuloendothelial system organs (the spleen and liver), followed by slower processing and clearance through the kidneys and bile."

According to the news reporters, the research concluded: "Original submitted 7 November 2012; Revised submitted 19 January 2013; Published online 9 July 2013."

For more information on this research see: Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine, 2014;9(2):221-236. Nanomedicine can be contacted at: Future Medicine Ltd, Unitec House, 3RD Floor, 2 Albert Place, Finchley Central, London, N3 1QB, England. (Elsevier -; Nanomedicine -

Our news correspondents report that additional information may be obtained by contacting S. Shukla, Case Western Reserve University, Dept. of Mat Sci & Engn, Cleveland, OH 44106, United States. Additional authors for this research include A.M. Wen, N.R. Ayat, U. Commandeur, R. Gopalkrishnan, A.M. Broome, K.W. Lozada, R.A. Keri and N.F. Steinmetz (see also Medical Nanotechnology).

Keywords for this news article include: Ohio, Cleveland, United States, Medical Nanotechnology, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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