News Column

Recent Findings in Controlled Release Described by Researchers from University of Milan

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Controlled Release are discussed in a new report. According to news reporting out of Milan, Italy, by NewsRx editors, research stated, "Polyamidic nanofibrous membranes containing gated silica mesoporous particles, acting as carriers, are described as novel hybrid composite materials for encapsulation and on-command delivery of garlic extracts. The carrier system consists of MCM-41 solids functionalized in the outer surface, with linear polyamines (solid PI) and with hydrolyzed starch (solid P2), both acting as molecular gates."

Our news journalists obtained a quote from the research from the University of Milan, "Those particles were adsorbed on electospun nylon-6 nanofibrous membranes yielding to composite materials M1 and M2. FE-SEM analysis confirmed the presence of particles incorporated on the nylon nanofibers. The release of the entrapped molecules (garlic extract) from the P1, P2, M1, and M2 materials was evaluated using cyclic voltammetry measurements. Electrochemical studies showed that at acidic pH P1 and M1 were unable to release their entrapped cargo (closed gate), whereas at neutral pH both materials release their loading (open gate). Dealing with P2 and M2 materials, in the absence of pancreatin a negligible release is observed (closed gate), whereas in the presence of enzyme the load is freely to diffuse to the solution."

According to the news editors, the research concluded: "These newly developed composite nanomaterials, provide a homogeneous easy-to-handle system with controlled delivery and bioactive-protective features, having potential applications on pharmacology, medical and engineering fields."

For more information on this research see: Polymer Composites Containing Gated Mesoporous Materials for On-Command Controlled Release. ACS Applied Materials & Interfaces, 2014;6(9):6453-6460. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; ACS Applied Materials & Interfaces -

Our news journalists report that additional information may be obtained by contacting C. Acosta, University of Milan, Dept. of Food Environm & Nutr Sci DeDENS, I-20122 Milan, Italy. Additional authors for this research include E. Perez-Esteve, C.A. Fuenmayor, S. Benedetti, M.S. Cosio, J. Soto, F. Sancenon, S. Mannino, J. Barat, M.D. Marcos and R. Martinez-Manez (see also Controlled Release).

Keywords for this news article include: Milan, Italy, Europe, Nanofibrous, Nanotechnology, Controlled Release, Emerging Technologies

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Source: Life Science Weekly

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