News Column

Recent Findings in Cancer Gene Therapy Described by Researchers from Southeast University

June 23, 2014

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Researchers detail new data in Biotechnology. According to news reporting originating in Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "S100P is a putative candidate oncogene in several types of human tumors. However, expression of S100P, its potential role and its clinical significance in gastric cancer remain unclear."

The news reporters obtained a quote from the research from Southeast University, "In the present study, S100P expression was examined by immunohistochemistry using a tissue microarray. Positive staining for S100P was noted in 77.1% of the cases while 22.9% were negative. In two gastric cancer cell lines, MGC-803 and SGC-7901, S100P expression was knocked down by a lentiviral short hairpin delivery system. The RNA interference-mediated downregulation of S100P expression markedly promoted cell apoptosis and inhibited cell colony-formation ability of the gastric cancer cells. In addition, knockdown of S100P significantly regulated the expression of 12 apoptosis-associated genes with a>1.5-fold change compared with the negative control. Among them, FOS, DDIT3 and FN1 were significantly upregulated, while FASLG, DAPK1, CTNNB1 and CASP2 were notably downregulated following S100P silencing."

According to the news reporters, the research concluded: "These results suggest that S100P acts as an oncogenic factor in gastric cancer and is a potential molecular target for gastric cancer gene therapy."

For more information on this research see: Knockdown of S100P by lentiviral-mediated RNAi promotes apoptosis and suppresses the colony-formation ability of gastric cancer cells. Oncology Reports, 2014;31(5):2344-50 (see also Biotechnology).

Our news correspondents report that additional information may be obtained by contacting Q. Zhang, Dept. of General Surgery, Zhongda Hospital, Southeast University, Gulou, Nanjing, Jiangsu 210009, People's Republic of China. Additional authors for this research include H. Hu, X. Shi and W. Tang.

Keywords for this news article include: Asia, Biotechnology, Jiangsu, Genetics, Oncology, Apoptosis, Gastric Cancer, Gastroenterology, Cancer Gene Therapy, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cancer Gene Therapy Week

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