News Column

Patent Application Titled "Neuromodulation to Treat Menopause-Related Conditions" Published Online

June 23, 2014



By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- According to news reporting originating from Washington, D.C., by NewsRx journalists, a patent application by the inventors Pless, Benjamin D. (Atherton, CA); Schuetz, Shannon (Atherton, CA), filed on November 29, 2013, was made available online on June 12, 2014 (see also Autonomic Technologies, Inc.).

The assignee for this patent application is Autonomic Technologies, Inc.

Reporters obtained the following quote from the background information supplied by the inventors: "Hot flashes are experienced by many women undergoing menopause. A hot flash is a feeling of warmth, sometimes associated with flushing, that spreads over the body and may be accompanied by perspiration. Hot flashes may vary in severity and may last for a short period of time in some women, but can last for a decade or more in other women. Although the cause of hot flashes is not completely understood, hot flashes may be related to fluctuations of hormone levels experienced during menopause. Hot flashes also may be experienced secondary to mastectomy and other cancer-related treatments, particularly cancer treatments that affect hormone levels.

"Traditionally, hot flashes have been treated with hormone therapy. Hormone replacement medications (usually estrogen or a combination of estrogen and progesterone) are effective in reducing the frequency of hot flashes and their severity. Generally, these medications decrease the frequency of hot flashes by about 80 to 90%. However, hormone replacement therapy is associated with increased risk of heart attack, stroke, blood clots, and breast cancer. Thus, alternative treatments are desirable.

"Neuromodulation involves an array of therapeutic approaches applied to the brain, cranial nerves, spinal cord, and all associated nerves and neural structures in the human body to treat various human disorders. Neuromodulation can involve lesioning, electrical stimulation/modulation, and chemical stimulation/modulation, such as gene therapy and administration of stem cells. Electrical stimulation of neural tissue is becoming an increasingly preferred form of therapy for certain conditions and disorders where existing therapies generate intolerable side effects, require repeated administration of treatment, or are simply ineffective in a subset of patients."

In addition to obtaining background information on this patent application, NewsRx editors also obtained the inventors' summary information for this patent application: "The present disclosure relates generally to neuromodulatory devices, systems and methods, and more particularly to devices, systems, and methods for neuromodulation of the sympathetic nervous system (SNS) to treat menopause-related conditions.

"One aspect of the present disclosure relates to a method for treating a menopause-related condition in a subject. One step of the method can include inserting a therapy delivery device into a vessel of the subject. Next, the therapy delivery device can be advanced to a point substantially adjacent a target site of the SNS that is associated with the menopause-related condition. The therapy delivery device can then be activated to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition.

"Another aspect of the present disclosure relates to a method for treating a menopause-related condition in a subject. One step of the method can include placing a therapy delivery device, without penetrating the skin of the subject, into electrical communication with a target site of the SNS that is associated with the menopause-related condition. The therapy delivery device can then be activated to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition.

"Another aspect of the present disclosure relates to a method for treating a menopause-related condition in a subject. One step of the method can include implanting a therapy delivery device in the subject so that the therapy delivery device is in electrical contact with a target site of the SNS associated with the menopause-related condition. The therapy delivery device can then be activated to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition.

BRIEF DESCRIPTION OF THE DRAWINGS

"The foregoing and other features of the present disclosure will become apparent to those skilled in the art to which the present disclosure relates upon reading the following description with reference to the accompanying drawings, in which:

"FIG. 1 is schematic illustration showing the cervical and upper thoracic portions of the sympathetic nerve chain and the spinal cord;

"FIG. 2 is a process flow diagram illustrating a method for treating a menopause-related condition in a subject according to one aspect of the present disclosure;

"FIG. 3 is a process flow diagram illustrating a method for treating a menopause-related condition in a subject according to another aspect of the present disclosure; and

"FIG. 4 is a process flow diagram illustrating a method for treating a menopause-related condition in a subject according to one aspect of the present disclosure."

For more information, see this patent application: Pless, Benjamin D.; Schuetz, Shannon. Neuromodulation to Treat Menopause-Related Conditions. Filed November 29, 2013 and posted June 12, 2014. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=1516&p=31&f=G&l=50&d=PG01&S1=20140605.PD.&OS=PD/20140605&RS=PD/20140605

Keywords for this news article include: Genetics, Hormones, Oncology, Estrogens, Menopause, Heart Attack, Endocrinology, Women's Health, Cancer Gene Therapy, Risk and Prevention, Myocardial Infarction, Autonomic Technologies Inc..

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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