News Column

New Supramolecular Research Findings Reported from Tokyo Medical and Dental University

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Supramolecular Research is now available. According to news reporting out of Tokyo, Japan, by NewsRx editors, research stated, "The effects of the supramolecular polyrotaxane (PRX) structure on cellular internalization are investigated by flow cytometry and confocal laser scanning microscopy. AF-545-labeled aminated PRXs (APRXs) containing different numbers of threaded ?-cyclodextrins (CDs) and amino groups are synthesized; their cellular uptakes are analyzed using HeLa cells in serum."

Our news journalists obtained a quote from the research from Tokyo Medical and Dental University, "The APRX threaded CD number is discovered to be a more critical factor for enhancing cellular internalization than the APRX amine content. Additionally, APRXs are demonstrated to be more easily internalized than conventional linear cationic macromolecules."

According to the news editors, the research concluded: "Because increased numbers of threaded CDs are related to increased PRX rigidity, the PRX rigid frame resulting from CD molecules threaded on a poly(ethylene glycol) (PEG) chain is suitable for intracellular tools in therapy and diagnosis."

For more information on this research see: Tailoring the supramolecular structure of aminated polyrotaxanes toward enhanced cellular internalization. Macromolecular Bioscience, 2014;14(3):359-68. (Wiley-Blackwell -; Macromolecular Bioscience -

Our news journalists report that additional information may be obtained by contacting N. Yokoyama, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo, 101-0062, Japan. Additional authors for this research include J.H. Seo, A. Tamura, Y. Sasaki and N. Yui (see also Supramolecular Research).

Keywords for this news article include: Asia, Tokyo, Japan, Nanotechnology, Emerging Technologies, Supramolecular Research, Supramolecular Structures.

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Source: Life Science Weekly