News Column

New Peptides and Proteins Study Results Reported from School of Chemical Sciences

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins. According to news originating from Stockholm, Sweden, by NewsRx correspondents, research stated, "A new instrumental concept for extraction of nanovolumes from open microchannels (dimensions 150 mu m x 50 mu m, length 10 mm) manufactured on silicon microchips has been used in combination with a previously developed method for preconcentrating proteins and peptides in the open channels through electromigration."

Our news journalists obtained a quote from the research from the School of Chemical Sciences, "The extracted nanovolumes were further analyzed using nanoelectrospray ionization (nESI) or matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) directly or with subsequent enzymatic protein digestion in a nanodroplet prior to the MS analysis. Preconcentration of the samples resulted in a 15-fold sensitivity increase in nESI for a neurotensin solution, and using MALDI-MS, amyloid beta (A beta) peptides could be detected in concentrations down to 1 nM."

According to the news editors, the research concluded: "The method was also successfully applied for detection of cell culture A beta."

For more information on this research see: Mass spectrometric analysis of nanoscale sample volumes extracted from open microchannels after sample preconcentration applied on amyloid beta peptides. Analytical and Bioanalytical Chemistry, 2014;406(14):3521-3524. Analytical and Bioanalytical Chemistry can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer -; Analytical and Bioanalytical Chemistry -

The news correspondents report that additional information may be obtained from S. Mikkonen, KTH Royal Inst Technol, Sch Chem Sci & Engn, Div Appl Phys Chem, Dept. of Chem, S-10044 Stockholm, Sweden. Additional authors for this research include J. Jacksen and A. Emmer (see also Proteins).

Keywords for this news article include: Sweden, Europe, Amyloid, Proteins, Stockholm, Nanoscale, Nanotechnology, Emerging Technologies

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Source: Life Science Weekly

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