News Column

New Neuroscience Data Have Been Reported by Investigators at Tufts University

June 23, 2014

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Nervous System Research. According to news reporting out of Medford, Massachusetts, by NewsRx editors, research stated, "Bundling of neurite extensions occur during nerve development and regeneration. Understanding the factors that drive neurite bundling is important for designing biomaterials for nerve regeneration toward the innervation target and preventing nociceptive collateral sprouting."

Our news journalists obtained a quote from the research from Tufts University, "High-density neuron cultures including dorsal root ganglia explants are employed for in vitro screening of biomaterials designed to control directional outgrowth. Although some semi-automated image processing methods exist for quantification of neurite outgrowth, methods to quantify axonal fasciculation in terms of direction of neurite outgrowth are lacking. New method: This work presents a semi-automated program to analyze micrographs of high-density neurites; the program aims to quantify axonal fasciculation by determining the orientational distribution function of the tangent vectors of the neurites and calculating its Fourier series coefficients ('c' values). We found that neurite directional distribution analysis (NDDA) of fasciculated neurites yielded 'c' values of >=similar to 0.25 whereas branched outgrowth led to statistically significant lesser values of
According to the news editors, the research concluded: "The NDDA is a valuable addition to open source image processing tools available to biomedical researchers offering a robust, precise approach to quantification of imaged features important in tissue development, disease, and repair."

For more information on this research see: Semi-automatic quantification of neurite fasciculation in high-density neurite images by the neurite directional distribution analysis (NDDA). Journal of Neuroscience Methods, 2014;228():100-109. Journal of Neuroscience Methods can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Journal of Neuroscience Methods -

Our news journalists report that additional information may be obtained by contacting A.M. Hopkins, Tufts University, Center Sci & Technol, Center Nanoscop Phys, Medford, MA 02155, United States. Additional authors for this research include B. Wheeler, C. Staii, D.L. Kaplan and T.J. Atherton (see also Nervous System Research).

Keywords for this news article include: Medford, Massachusetts, United States, Nervous System Research, North and Central America

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Source: Pain & Central Nervous System Week

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