News Column

New Neurons Findings from J. Ahn and Co-Researchers Reported

June 26, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A new study on Neurons is now available. According to news originating from Suwon, South Korea, by NewsRx correspondents, research stated, "Glycogen synthase kinase 3 (GSK3) acts as an important regulator during the proliferation and differentiation of neural progenitor cells (NPCs), but the roles of the isoforms of this molecule (GSK3 and GSK3) have not been clearly defined. In this study, we investigated the functions of GSK3 and GSK3 in the context of neuronal differentiation of murine NPCs."

Our news journalists obtained a quote from the research, "Treatment of primary NPCs with a GSK3 inhibitor (SB216763) resulted in an increase in the percentage of TuJ1-positive immature neurons, suggesting an inhibitory role of GSK3 in embryonic neurogenesis. Downregulation of GSK3 expression increased the percentage of TuJ1-positive cells, while knock-down of GSK3 seemed to have no effect. When primary NPCs were engineered to stably express either isoform of GSK3 using retroviral vectors, GSK3, but not GSK3, inhibited neuronal differentiation and helped the cells to maintain the characteristics of NPCs. Mutant GSK3 (Y216F) failed to suppress neuronal differentiation, indicating that the kinase activity of GSK3 is important for this regulatory function. Similar results were obtained in vivo when a retroviral vector expressing GSK3 was delivered to E9.5 mouse brains using the ultrasound image-guided gene delivery technique. In addition, SB216763 was found to block the rapamycin-mediated inhibition of neuronal differentiation of NPCs."

According to the news editors, the research concluded: "Taken together, our results demonstrate that GSK3, but not GSK3, negatively controls the neuronal differentiation of progenitor cells and that GSK3 may act downstream of the mammalian target of rapamycin complex1 signaling pathway."

For more information on this research see: GSK3b, But Not GSK3a, Inhibits the Neuronal Differentiation of Neural Progenitor Cells As a Downstream Target of Mammalian Target of Rapamycin Complex1. Stem Cells and Development, 2014;23(10):1121-1133. Stem Cells and Development can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. -; Stem Cells and Development -

The news correspondents report that additional information may be obtained from J. Ahn, Sungkyunkwan UniversitySch Biotechnol & Bioengn, Suwon, South Korea. Additional authors for this research include J. Jang, J. Choi, J. Lee, S.H. Oh, J. Lee, K. Yoon and S. Kim (see also Neurons).

Keywords for this news article include: Asia, Suwon, Cells, Kinase, Neurons, South Korea, Enzymes and Coenzymes

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Source: Gene Therapy Weekly

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