By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Gram-Negative Bacterial Infections. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Silica/polydopamine/silver (SiO2/PD/Ag) nanoparticles (NPs) with a core-shell-satellite structure were fabricated and the mechanisms of their antibacterial activity were investigated. In this reported work, the results of the reactive oxygen species (ROS) assays, the deoxyribonucleic acid (DNA) damage assays and a cell morphology observation confirmed that Vibrio natriegens, a gram negative bacterium and Bacillus subtilis, a gram positive bacterium could be inhibited by the NPs."
Our news journalists obtained a quote from the research from Shanghai Maritime University, "Gram negative bacteria exhibited more sensitivity towards the Ag NPs because these NPs were associated with penetration into the cytoplasm, with the subsequent local interaction of Ag with the cell components; thus, causing damages to the cells. SiO2/PD/Ag NPs produced ROS which caused damage to the DNA leading to the suppression of transcription as detected by a reporter gene assay. Furthermore, ROS induced membrane damage was determined by transmission electron microscopy. Thus, the mechanisms of antibacterial activity were interpreted more precisely by using the aforementioned experiments."
According to the news editors, the research concluded: "The results revealed that the production of ROS and damage to the membrane were the two major mechanisms of the bactericidal action of SiO2/PD/Ag NPs; thus, these NPs could be employed as effective antifouling agents."
For more information on this research see: Antibacterial mechanisms of silica/polydopamine/silver nanoparticles against gram positive and gram negative bacteria. Micro & Nano Letters, 2014;9(3):210-214. Micro & Nano Letters can be contacted at: Inst Engineering Technology-Iet, Michael Faraday House Six Hills Way Stevenage, Hertford SG1 2AY, England (see also Gram-Negative Bacterial Infections).
The news correspondents report that additional information may be obtained from Z.W. Guo, Shanghai Maritime Univ, Coll Marine Sci & Engn, Shanghai 201306, People's Republic of China. Additional authors for this research include J.Z. Xue, T. Liu, X. Song, Y.Y. Shen and H.X. Wu.
Keywords for this news article include: Asia, Shanghai, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China, Gram-Negative Bacterial Infections
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