News Column

New Gene Therapy Study Results from New University of Lisbon Described

June 26, 2014



By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A new study on Biotechnology is now available. According to news originating from Oeiras, Portugal, by NewsRx correspondents, research stated, "Recombinant adenoviruses (AdV) are highly efficient at gene transfer for a broad spectrum of cell types and species. They became one of the vectors of choice for gene delivery and expression of foreign proteins in gene therapy and vaccination purposes."

Our news journalists obtained a quote from the research from the New University of Lisbon, "To meet the need of significant amounts of adenoviral vectors for preclinical and possibly clinical uses, scalable and reproducible production processes are required.In this chapter, we review processes used for scalable production of two types of first generation (E1-deleted) adenoviral vectors (Human and Canine) using stirred tank bioreactors. The production of adenovirus vectors using either suspension (HEK 293) or anchorage-dependent cells (MDCK-E1) are described to exemplify scalable production processes with different cell-culture types."

According to the news editors, the research concluded: "The downstream processes will be covered in the next chapter."

For more information on this research see: Scalable production of adenovirus vectors. Methods In Molecular Biology, 2014;1089():175-96 (see also Biotechnology).

The news correspondents report that additional information may be obtained from A.C. Silva, Animal Cell Technology Unit, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa (ITQB-UNL), Oeiras, Portugal. Additional authors for this research include P. Fernandes, M.F. Sousa and P.M Alves.

Keywords for this news article include: Biotechnology, Oeiras, Europe, Portugal, Adenovirus, Gene Therapy, Bioengineering.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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