By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Proteins are discussed in a new report. According to news reporting originating in Kashan, Iran, by NewsRx journalists, research stated, "In this article, we introduce a new method for preparing ultrasmall chitosan (CS)/succinyl beta-cyclodextrin (SCD) nanoparticles (NPs) intended for loading bovine serum albumin (BSA) as a model protein. The proposed method is based on the complex coacervation technique followed by ionotropic gelation with tripolyphosphate."
The news reporters obtained a quote from the research from Islamic Azad University, "SCD, an anionic derivative of cyclodextrin, was synthesized and used in CS-based NPs to enhance the entrapment efficiency of BSA. The results show that with this approach, ultrasmall, compact, and neutralized NPs with a mean particle size near 30 nm were obtained. A high degree of protein entrapment in the NPs led to a significant improvement in the BSA release profile with a low initial burst release (ca. 3% w/v of the initially loaded BSA) and a sustained release over time."
According to the news reporters, the research concluded: "This enabled a suitable nanocarrier for long-term protein delivery (30% release over 120 h)."
For more information on this research see: Development of Ultrasmall Chitosan/Succinyl beta-Cyclodextrin Nanoparticles as a Sustained Protein-Delivery System. Journal of Applied Polymer Science, 2014;131(1):227-232. Journal of Applied Polymer Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Polymer Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4628)
Our news correspondents report that additional information may be obtained by contacting S. Taranejoo, Islamic Azad Univ, Kashan Branch, Kashan, Iran. Additional authors for this research include S. Monemian, M. Moghri and H. Derakhshankhah (see also Proteins).
Keywords for this news article include: Iran, Asia, Kashan, Proteins, Nanoparticle, Nanotechnology, Bovine Serum Albumin, Emerging Technologies
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