News Column

New Dengue Findings Has Been Reported by Researchers at Duke University Medical Center

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Mosquito-Borne Diseases are discussed in a new report. According to news reporting originating in Durham, North Carolina, by NewsRx journalists, research stated, "Dengue virus (DENV) is endemic throughout tropical regions of the world and there are no approved treatments or anti-transmission agents currently available. Consequently, there exists an enormous unmet need to treat the human diseases caused by DENV and block viral transmission by the mosquito vector."

The news reporters obtained a quote from the research from Duke University Medical Center, "RNAi screening represents an efficient method to expand the pool of known host factors that could become viable targets for treatments or provide rationale to consider available drugs as anti-DENV treatments. We developed a high-throughput siRNA-based screening protocol that can identify human DENV host factors."

According to the news reporters, the research concluded: "The protocol herein describes the materials and the procedures necessary to screen a human cell line in order to identify genes which are either necessary for or restrict DENV propagation at any stage in the viral life cycle."

For more information on this research see: Functional genomics approach for the identification of human host factors supporting dengue viral propagation. Methods In Molecular Biology, 2014;1138():285-99 (see also Mosquito-Borne Diseases).

Our news correspondents report that additional information may be obtained by contacting N.J. Barrows, Program in Cell and Molecular Biology, Dept. of Molecular Genetics and Microbiology, Center for RNA Biology, Duke University Medical Center, Durham, NC, United States. Additional authors for this research include S.F. Jamison, S.S. Bradrick, C. Le Sommer, S.Y. Kim, J. Pearson and M.A Garcia-Blanco.

Keywords for this news article include: Durham, RNA Viruses, Dengue Fever, United States, North Carolina, Arbovirus Infections, Flavivirus Infections, Flaviviridae Infections, Mosquito-Borne Diseases, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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