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New Data from Huazhong University of Science and Technology Illuminate Findings in Ventilator-Induced Lung Injury

June 23, 2014

By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Investigators publish new report on Lung Diseases and Conditions. According to news reporting originating in Wuhan, People's Republic of China, by NewsRx journalists, research stated, "Mechanical ventilation can cause structural and functional disturbances in the lung termed ventilator-induced lung injury (VILI). The aim of this study was to evaluate whether BML-111, a lipoxin receptor agonist, could attenuate VILI."

The news reporters obtained a quote from the research from the Huazhong University of Science and Technology, "Following induction of anesthesia and tracheostomy, Sprague-Dawley rats were ventilated with low tidal volume (6 mL/kg) or high tidal volume (20 mL/kg, HVT) for 4 h. Some rats subjected to HVT ventilation received BML-111 or vehicle (saline) by intraperitoneal injection. Some rats subjected to HVT and BML-111(1 mg/kg) received BOC-2 (a FPR2/ALX antagonist) intraperitoneally 30 min before BML-111. Sham rats were tracheotomized without ventilation. Treatment with BML-111 attenuated VILI, as evidenced by improved oxygenation and reduced histological injury compared with HVT-induced lung injury. BML-111 decreased indices of inflammation such as interleukin 1, interleukin 6, tumor necrosis factor , and bronchoalveolar lavage neutrophil infiltration. Administration with BML-111 suppressed the decrement of the nuclear factor B (NF-B) inhibitor IB-, diminished NF-B activation, and reduced activation of mitogen-activated protein kinase in VILI. This study indicates that BML-111 attenuated VILI via a NF-B and mitogen-activated protein kinase dependent mechanism."

According to the news reporters, the research concluded: "BML-111 may be a promising strategy for alleviation of VILI in patients subjected to mechanical ventilation."

For more information on this research see: Bml-111, A Lipoxin Receptor Agonist, Attenuates Ventilator-induced Lung Injury In Rats. Shock, 2014;41(4):311-316. Shock can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins -; Shock -

Our news correspondents report that additional information may be obtained by contacting H.B. Li, Huazhong University of Science & Technology, Tongji Med College, Union Hosp, Dept. of Crit Care MedInst Anesthesia & Crit Care, Wuhan 430022, People's Republic of China. Additional authors for this research include Z.Y. Wu, D. Feng, J. Gong, C.Y. Yao, Y.X. Wang, S.Y. Yuan, S.L. Yao and Y. Shang (see also Lung Diseases and Conditions).

Keywords for this news article include: Asia, Wuhan, Kinase, Lipoxin Receptors, Membrane Proteins, Eicosanoid Receptors, Enzymes and Coenzymes, People's Republic of China, Respiratory Tract Diseases, Lung Diseases and Conditions, Ventilator-Induced Lung Injury

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Source: Respiratory Therapeutics Week

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