News Column

New Data from Flinders University of South Australia Illuminate Findings in Gene Therapy

June 26, 2014



By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators discuss new findings in Biotechnology. According to news originating from Adelaide, Australia, by NewsRx correspondents, research stated, "To create advanced functional nanocarriers for achieving excellent gene delivery performance, fluorescence label-free hybridized dendrimer-like silica nanocarriers (HPSNs-AC-PEI) were developed by using the endosomal pH and cytoplasmic glutathione (GSH) responsive autofluorescent acetaldehyde-modified-cystine (AC) to link non-toxic low molecular weight branched polyethyleneimine (PEI) onto amino-functionalized dendrimer-like silica nanoparticles with hierarchical pores (HPSNs-NH2)."

Our news journalists obtained a quote from the research from the Flinders University of South Australia, "The specific microstructure of this hybridized nanocarrier makes it not only show low cytotoxicity and high gene loading capability, but also display high gene transfection efficiency. The cleavage of disulfide bonds caused by GSH facilitates plasmid DNA (pDNA) release."

According to the news editors, the research concluded: "Moreover, the pH and GSH controlled gene delivery profile can be real-time tracked using the autofluorescence of HPSNs-AC-PEI."

For more information on this research see: Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery. Biomaterials, 2014;35(21):5580-5590. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

The news correspondents report that additional information may be obtained from X. Du, Flinders University of South Australia, Sch Comp Sci Engn & Math, Center Nano Scale Sci & Technol, Adelaide, SA 5042, Australia. Additional authors for this research include B.Y. Shi, Y.H. Tang, S. Dai and S.Z. Qiao (see also Biotechnology).

Keywords for this news article include: Biotechnology, Adelaide, Gene Therapy, Nanocarriers, Bioengineering, Nanotechnology, Emerging Technologies, Australia and New Zealand

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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