News Column

Findings on Cancer Gene Therapy Discussed by Investigators at Ghent University

June 23, 2014



By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Researchers detail new data in Biotechnology. According to news reporting from Ghent, Belgium, by NewsRx journalists, research stated, "While conventional chemotherapy regimens aim to be cytotoxic against proliferating cells, molecular targeted therapies are directed at specific cancer-associated pathways. To optimize cancer care, an early evaluation of treatment response is warranted for any tumor type - and for any treatment - by using conventional imaging modalities such as ultrasound, CT and MR, FDG-PET or specific radiotracer."

The news correspondents obtained a quote from the research from Ghent University, "FDG-PET is one of the most extensively and successfully used imaging modalities to achieve an early response evaluation. A high SUV-value is a surrogate for malignancy in terms of cancer care and a decrease in FDG-uptake after therapy is associated with treatment response and a favorable clinical outcome. Anyhow, the potential of PET reaches further. By providing metabolic information PET (with or without CT) can help to select patients for targeted therapy and to adapt treatment protocols. PET with FDG and maybe other, more specific PET tracers, promises to direct in a better way personalized cancer care and thus promote translational research. An interesting aspect of molecular imaging is the ability to achieve knowledge on distribution and expression levels of a given receptor. Hereby, imaging could help in guiding systemic treatment given a broad spectrum of radiotracers, detecting specific mutations at molecular level in vivo."

According to the news reporters, the research concluded: "From an oncologists point of view the concept of 'personalized medicine' should evolve to include 'personalized imaging' as well as 'personalized treatment' in order to optimize cancer care, reduce side effects and improve quality of life for cancer patients."

For more information on this research see: Imaging Requirements for Personalized Medicine: The Oncologists Point of View. Current Pharmaceutical Design, 2014;20(14):2234-2249. Current Pharmaceutical Design can be contacted at: Bentham Science Publ Ltd, Executive Ste Y-2, PO Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates. (Bentham Science Publishers - www.benthamscience.com; Current Pharmaceutical Design - www.benthamscience.com/cpd/index.htm)

Our news journalists report that additional information may be obtained by contacting V. Kruse, University of Ghent, Heymans Inst Pharmacol, B-9000 Ghent, Belgium. Additional authors for this research include S. Van Belle and V. Cocquyt (see also Biotechnology).

Keywords for this news article include: Biotechnology, Ghent, Europe, Belgium, Genetics, Oncology, Cancer Gene Therapy, Personalized Medicine

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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