News Column

Findings in the Area of Apoptosis Reported from Singapore National University

June 27, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Apoptosis is the subject of a report. According to news reporting from Singapore, Singapore, by NewsRx journalists, research stated, "Nanomaterials (NMs) such as titanium dioxide (nano-TiO2) and hydroxyapatite (nano-HA) are widely used in food, personal care, and many household products. Due to their extensive usage, the risk of human exposure is increased and may trigger NMs specific biological outcomes as the NMs interface with the cells."

The news correspondents obtained a quote from the research from Singapore National University, "However, the interaction of nano-TiO2 and nano-HA with cells, their uptake and subcellular distribution, and the cytotoxic effects are poorly understood. Herein, we characterized and examined the cellular internalization, inflammatory response and cytotoxic effects of nano-TiO2 and nano-HA using TR146 human oral buccal epithelial cells as an in vitro model. We showed both types of NMs were able to bind to the cellular membrane and passage into the cells in a dose dependent manner. Strikingly, both types of NMs exhibited distinct subcellular distribution profile with nano-HA displaying a higher preference to accumulate near the cell membrane compared to nano-TiO2. Exposure to both types of NMs caused an elevated reactive oxygen species (ROS) level and expression of inflammatory transcripts with increasing NMs concentration. Although cells treated with nano-HA induces minimal apoptosis, nano-TiO2 treated samples displayed approximately 28% early apoptosis after 24 h of NMs exposure. We further showed that nano-TiO2 mediated cell death is independent of the classical p53-Bax apoptosis pathway."

According to the news reporters, the research concluded: "Our findings provided insights into the potential cellular fates of human oral epithelial cells as they interface with industrial grade nano-HA and nano-TiO2."

For more information on this research see: Nano-hydroxyapatite and Nano-titanium Dioxide Exhibit Different Subcellular Distribution and Apoptotic Profile in Human Oral Epithelium. ACS Applied Materials & Interfaces, 2014;6(9):6248-6256. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; ACS Applied Materials & Interfaces -

Our news journalists report that additional information may be obtained by contacting C.Y. Tay, Singapore National University, Fac Dental, Singapore 119083, Singapore. Additional authors for this research include W.R. Fang, M.I. Setyawati, S.L. Chia, K.S. Tan, C.H.L. Hong and D.T. Leong (see also Apoptosis).

Keywords for this news article include: Asia, Apoptosis, Chemicals, Chemistry, Phosphates, Light Metals, Hydroxyapatites, Phosphoric Acids, Titanium Dioxide

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Source: Health & Medicine Week

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