News Column

Findings in Enzymes and Coenzymes Reported from Changchun Institute of Applied Chemistry

June 23, 2014



By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Research findings on Enzymes and Coenzymes are discussed in a new report. According to news reporting originating in Changchun, People's Republic of China, by NewsRx journalists, research stated, "It is highly desirable and challenging when the chemzyme can be not only simply duplicating and imitating the properties of natural enzymes, but also introducing additional new features for practical applications. Herein, we report a zinc-finger-protein like -helical chiral metallo-supramolecular complex ([Fe2L3](4+)) functionalized graphene oxide (GO-COOH) as a peroxidase mimic."

The news reporters obtained a quote from the research from the Changchun Institute of Applied Chemistry, "This artificial enzyme integrates the characteristics of both chiral metallo-supramolecular complex and GO-COOH, and shows excellent catalytic activity. More intriguingly, the novel chemzyme turn out to have enantioselectivity and near-infrared photothermal effect. To the best of our knowledge, this is the first example that the chemzyme has such new features. Based on these properties, we have demonstrated three examples for the applications of our designed enzyme: 1) Intracellular H2O2 detection in PC12 cells against Alzheimer's disease; 2) Discrimination between the chiral drug, Levodopa (L-dopa), the gold standard for treating Parkinson's disease and its enantiomer, D-dopa. This is important because L-dopa is the most effective drug at present used to combat Parkinson's disease while D-dopa is inactive and can even cause side effects, thus for drug efficacy it must be free of D-dopa in the formulation; 3) Remote control of enzyme cascade biocatalysis reactions using high transparent, bio-friendly near-infrared (NIR) light. NIR allows remote activation with relatively high spatial and temporal precision."

According to the news reporters, the research concluded: "Our work will provide new insights into design and construction of novel chemzyme with more advanced features beyond intrinsic enzyme property."

For more information on this research see: Artificial Evolution of Graphene Oxide Chemzyme with Enantioselectivity and Near-Infrared Photothermal Effect for Cascade Biocatalysis Reactions. Small, 2014;10(9):1841-1847. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)

Our news correspondents report that additional information may be obtained by contacting C. Xu, Chinese Academy Sci, State Key Lab Rare Earth Resource Utilizat, Changchun Inst Appl Chem, Div Biol Inorgan ChemGrad Sch, Changchun 130022, Jilin, People's Republic of China. Additional authors for this research include C.Q. Zhao, M. Li, L. Wu, J.S. Ren and X.G. Qu (see also Enzymes and Coenzymes).

Keywords for this news article include: Asia, Changchun, Nanotechnology, Supramolecular, Emerging Technologies, Enzymes and Coenzymes, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Pain & Central Nervous System Week


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