By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Nanotechnology have been published. According to news reporting out of Hangzhou, People's Republic of China, by NewsRx editors, research stated, "The toxicity of ZnO nanoparticles (NPs) has been widely investigated because of their extensive use in consumer products. The mechanism of the toxicity of ZnO NPs to algae is unclear, however, and it is difficult to differentiate between particle-induced toxicity and the effect of dissolved Zn2+."
Our news journalists obtained a quote from the research from the Zhejiang University of Technology, "In the work discussed in this paper we investigated particle-induced toxicity and the effects of dissolved Zn2+ by using the chiral perturbation approach with dichlorprop (DCPP) as chiral perturbation factor. The results indicated that intracellular zinc is important in the toxicity of ZnO NPs, and that ZnO NPs cause oxidative damage. According to dose-response curves for DCPP and the combination of ZnO NPs with ®-DCPP or (S)-DCPP, the toxicity of DCPP was too low to perturb the toxicity of ZnO NPs, so DCPP was suitable for use as chiral perturbation factor. The different glutathione (GSH) content of algal cells exposed to ®-DCPP or (S)-DCPP correlated well with different production of reactive oxygen species (ROS) after exposure to the two enantiomers. Treatment of algae with ZnO NPs and ®-DCPP resulted in reduced levels of GSH and the glutathione/oxidized glutathione (GSH/GSSG) ratio in the cells compared with the control. Treatment of algae with ZnO NPs and (S)-DCPP, however, resulted in no significant changes in GSH and GSH/GSSG. Moreover, trends of variation of GSH and GSH/GSSG were different when algae were treated with ZnSO4 center dot 7H(2)O and the two enantiomers."
According to the news editors, the research concluded: "Overall, the chiral perturbation approach revealed that NPs aggravated generation of ROS and that released Zn2+ and NPs both contribute to the toxicity of ZnO NPs."
For more information on this research see: Evaluation of the toxicity of ZnO nanoparticles to Chlorella vulgaris by use of the chiral perturbation approach. Analytical and Bioanalytical Chemistry, 2014;406(15):3689-3695. Analytical and Bioanalytical Chemistry can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Analytical and Bioanalytical Chemistry - www.springerlink.com/content/1618-2642/)
Our news journalists report that additional information may be obtained by contacting H. Zhou, Zhejiang University of Technology, Res Center Anal & Measurement, Hangzhou 310032, Zhejiang, People's Republic of China. Additional authors for this research include X.J. Wang, Y. Zhou, H.Z. Yao and F. Ahmad (see also Nanotechnology).
Keywords for this news article include: Asia, Hangzhou, Zinc Oxide, Glutathione, Nanoparticle, Oligopeptides, Nanotechnology, Emerging Technologies, People's Republic of China
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