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Findings from University of Texas Broaden Understanding of Nanoparticles

June 24, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Nanoparticles. According to news reporting out of Houston, Texas, by NewsRx editors, research stated, "Endothelial cells are dynamic cells tasked with selective transport of cargo from blood vessels to tissues. Here we demonstrate the potential for nanoparticle transport across endothelial cells in membrane-bound vesicles."

Our news journalists obtained a quote from the research from the University of Texas, "Cell-free endothelial-derived biovesicles were characterized for cellular and nanoparticle content by electron microscopy. Confocal microscopy was used to evaluate biovesicles for organelle-specific proteins, and to monitor biovesicle engulfment by naive cells. Nanoparticle-laden biovesicles containing low-density polyethyleneimine nanoparticles appear to be predominately of endosomal origin, combining features of multivesicular bodies, lysosomes and autophagosomes. Conversely, high-density polyethyleneimine nanoparticles stimulate the formation of biovesicles associated with cellular apoptotic breakdown. Secreted LAMP-1-positive biovesicles are internalized by recipient cells, either of the same origin or of novel phenotype."

According to the news editors, the research concluded: "Cellular biovesicles, rich in cellular signals, present an important mode of cell-to-cell communication either locally or through broadcasting of biological messages."

For more information on this research see: Cellular communication via nanoparticle-transporting biovesicles. Nanomedicine, 2014;9(5):581-592. Nanomedicine can be contacted at: Future Medicine Ltd, Unitec House, 3RD Floor, 2 Albert Place, Finchley Central, London, N3 1QB, England. (Elsevier - www.elsevier.com; Nanomedicine - www.elsevier.com/wps/product/cws_home/703416)

Our news journalists report that additional information may be obtained by contacting S. Ferrati, Univ Texas MD Anderson Canc Center, Dept. of Pediat, Houston, TX 77030, United States. Additional authors for this research include K.I. McConnell, A.C. Mack, N. Sirisaengtaksin, R. Diaz, A.J. Bean, M. Ferrari and R.E. Serda (see also Nanoparticles).

Keywords for this news article include: Texas, Houston, United States, Nanotechnology, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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