News Column

Findings from University of Jaume Update Understanding of Oligopeptides

June 24, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Peptides. According to news reporting from Castellon de la Plana, Spain, by NewsRx journalists, research stated, "The molecular recognition of short peptides is a challenge in supramolecular chemistry, and the use of peptide-like cage receptors represents a promising approach. Here we report the synthesis and characterization of a diverse family of pseudopeptidic macrobicycles, as well as their binding abilities toward N-protected dipeptides using a combination of different techniques (NMR, ESI-MS, and fluorescence spectroscopy)."

The news correspondents obtained a quote from the research from the University of Jaume, "The cage hosts were assayed for dipeptide binding using competition ESI-MS experiments as high-throughput screening to obtain general trends for the recognition phenomena. Selected hosts were additionally studied by NMR spectroscopy (H-1 NMR titration and diffusion-ordered spectroscopy experiments) in different solvents. The results unambiguously demonstrated the formation of the [cage.dipeptide] supramolecular complexes and rendered quantitative information about the strength of the interaction (K-ass). The structural variables within the pseudopeptidic cage framework that produced a stronger and more selective recognition were thus identified. The cages showed a remarkable selectivity for N-protected dipeptides with an aromatic amino acid at the carboxylic terminus, which prompted us to propose a mode of binding based on polar and nonpolar noncovalent interactions."

According to the news reporters, the research concluded: "Accordingly, we faced the molecular recognition of a target dipeptide (Ac-EY-OH) mimicking a biologically relevant sequence by NMR and fluorescence spectroscopy in highly competitive media."

For more information on this research see: Pseudopeptidic Cages as Receptors for N-Protected Dipeptides. Journal of Organic Chemistry, 2014;79(10):4590-4601. Journal of Organic Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Journal of Organic Chemistry -

Our news journalists report that additional information may be obtained by contacting E. Faggi, University of Jaume, Dept. of Quim Inorgan & Organ, E-12071 Castellon de La Plana, Spain. Additional authors for this research include A. Moure, M. Bolte, C. Vicent, S.V. Luis and I. Alfonso (see also Peptides).

Keywords for this news article include: Spain, Europe, Dipeptides, Oligopeptides, Nanotechnology, Supramolecular, Castellon de la Plana, Emerging Technologies, Molecular Recognition

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Source: Life Science Weekly

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