News Column

Findings from University of Amsterdam in Cardiovascular Research Reported

June 23, 2014

By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on Cardiovascular Research. According to news reporting originating from Amsterdam, Netherlands, by NewsRx correspondents, research stated, "The extracellular matrix (ECM) is best known for its function as a structural scaffold for the tissue and more recently as a microenvironment to sequester growth factors and cytokines allowing for rapid and localized changes in their activity in the absence of new protein synthesis. In this review, we explore this and additional new aspects of ECM function in mediating cell-to-cell communications."

Our news editors obtained a quote from the research from the University of Amsterdam, "Fibrillar and nonfibrillar components of ECM can limit and facilitate the transport of molecules through the extracellular space while also regulating interstitial hydrostatic pressure. In turn, transmembrane communications via molecules, such as ECM metalloproteinase inducer, thrombospondins, and integrins, can further mediate cell response to extracellular cues and affect ECM composition and tissue remodeling. Other means of cell-to-cell communication include extracellular microRNA transport and its contribution to gene expression in target cells and the nanotube formation between distant cells, which has recently emerged as a novel conduit for intercellular organelle sharing thereby influencing cell survival and function."

According to the news editors, the research concluded: "The information summarized and discussed here are not limited to the cardiovascular ECM but encompass ECM in general with specific references to the cardiovascular system."

For more information on this research see: Matrix as an Interstitial Transport System. Circulation Research, 2014;114(5):889-902. Circulation Research can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Cardiovascular Research).

The news editors report that additional information may be obtained by contacting D. Fan, University of Amsterdam, Academy Med Center, Heart Failure Res Center, NL-1105 AZ Amsterdam, Netherlands. Additional authors for this research include E.E. Creemers and Z. Kassiri.

Keywords for this news article include: Europe, Amsterdam, Cardiology, Netherlands, Cardiovascular Research

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Source: Cardiovascular Week

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