News Column

Data on Breast Cancer Detailed by Researchers at Hanyang University

June 26, 2014

By a News Reporter-Staff News Editor at Women's Health Weekly -- Researchers detail new data in Oncology. According to news reporting originating from Ansan, South Korea, by NewsRx correspondents, research stated, "We report a surface-enhanced Raman scattering (SERS)-based cellular imaging technique to detect and quantify breast cancer phenotypic markers expressed on cell surfaces. This technique involves the synthesis of SERS nano tags consisting of silica-encapsulated hollow gold nanospheres (SEHGNs) conjugated with specific antibodies."

Our news editors obtained a quote from the research from Hanyang University, "Hollow gold nanospheres (HGNs) enhance SERS signal intensity of individual particles by localizing surface electromagnetic fields through pinholes in the hollow particle structures. This capacity to enhance imaging at the level of single molecules permits the use of HGNs to detect specific biological markers expressed in living cancer cells. In addition, silica encapsulation greatly enhances the stability of nanoparticles. Here we applied a SERS-based imaging technique using SEHGNs in the multiplex imaging of three breast cancer cell phenotypes. Expression of epidermal growth factor (EGF), ErbB2, and insulin-like growth factor-1 (IGF-1) receptors were assessed in the MDA-MB-468, KPL4 and SK-BR-3 human breast cancer cell lines. SERS imaging technology described here can be used to test the phenotype of a cancer cell and quantify proteins expressed on the cell surface simultaneously."

According to the news editors, the research concluded: "Based on results, this technique may enable an earlier diagnosis of breast cancer than is currently possible and offer guidance in treatment."

For more information on this research see: Rapid and sensitive phenotypic marker detection on breast cancer cells using surface-enhanced Raman scattering (SERS) imaging. Biosensors & Bioelectronics, 2014;51():238-43. (Elsevier -; Biosensors & Bioelectronics -

The news editors report that additional information may be obtained by contacting S. Lee, Dept. of Bionano Engineering, Hanyang University, Ansan 426-791, South Korea. Additional authors for this research include H. Chon, J. Lee, J. Ko, B.H. Chung, D.W. Lim and J. Choo (see also Oncology).

Keywords for this news article include: Asia, Ansan, Oncology, Nanosphere, South Korea, Breast Cancer, Nanotechnology, Women's Health, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Women's Health Weekly

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